Cao Yu, Jia Man, Duan Chunyan, Yang Zhihui, Cheng Bo, Wang Ronghao
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.
Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Front Pharmacol. 2024 Aug 29;15:1448872. doi: 10.3389/fphar.2024.1448872. eCollection 2024.
Prostate cancer (PCa) is the second leading cause of cancer-related death among men in western countries. Evidence has indicated the significant role of the androgen receptor (AR) as the main driving factor in controlling the development of PCa, making androgen receptor inhibition (ARI) therapy a pivotal management approach. In addition, AR independent signaling pathways also contribute to PCa progression. One such signaling pathway that has garnered our attention is N6-Methyladenosine (mA) signaling, which refers to a chemical modification on RNA with crucial roles in RNA metabolism and disease progression, including PCa. It is important to comprehensively summarize the role of each individual mA regulator in PCa development and understand its interaction with AR signaling. This review aims to provide a thorough summary of the involvement of mA regulators in PCa development, shedding light on their upstream and downstream signaling pathways. This summary sets the stage for a comprehensive review that would benefit the scientific community and clinical practice by enhancing our understanding of the biology of mA regulators in the context of PCa.
前列腺癌（PCa）是西方国家男性癌症相关死亡的第二大主要原因。有证据表明，雄激素受体（AR）作为控制PCa发展的主要驱动因素发挥着重要作用，这使得雄激素受体抑制（ARI）疗法成为一种关键的治疗方法。此外，AR非依赖性信号通路也有助于PCa的进展。其中一个引起我们关注的信号通路是N6-甲基腺苷（m6A）信号通路，它指的是RNA上的一种化学修饰，在RNA代谢和包括PCa在内的疾病进展中起着关键作用。全面总结每个m6A调节因子在PCa发展中的作用并了解其与AR信号通路的相互作用非常重要。本综述旨在全面总结m6A调节因子在PCa发展中的参与情况，阐明其上游和下游信号通路。这一总结为全面综述奠定了基础，通过加强我们对PCa背景下m6A调节因子生物学的理解，将使科学界和临床实践受益。
