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龙胆苦苷通过抑制炎症反应改善脓毒症诱导的急性肺损伤。

Gentiopicroside Ameliorates Sepsis-Induced Acute Lung Injury via Inhibiting Inflammatory Response.

机构信息

Department of Orthopedics Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai 201801, China.

Department of Critical Care Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Can Respir J. 2024 Sep 5;2024:1068326. doi: 10.1155/2024/1068326. eCollection 2024.

DOI:10.1155/2024/1068326
PMID:39268525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11392574/
Abstract

Sepsis is a systemic inflammatory reaction syndrome caused by infections. Acute lung injury (ALI) occurs first and most frequently in patients with sepsis. Gentiopicroside (GPS), which originates mostly from is classified as a secoiridoid glycosides. Terpenoid glycosides have various biological effects, including liver protection, blood glucose and cholesterol level management, and anti-inflammatory and antitumor effects. However, presently, the biochemical foundation and mechanism of the anti-inflammatory effects of GPS in sepsis-induced ALI have not been explained. In the present study, we established a rat model of sepsis ALI induced by cecal ligation and puncture. This enables us to observe the effects of GPS therapy, which significantly reduced the inflammatory response (TNF-, IL-1, and IL-6), nitrogen stress, oxidative stress, and severity of ALI at both the whole animal and molecular levels. In addition, GPS ameliorates LPS-induced ALI via regulation of inflammatory response and cell proptosis in BEAS-2B. This study provides a theoretical basis for treating sepsis-induced ALI with GPS.

摘要

脓毒症是由感染引起的全身炎症反应综合征。急性肺损伤（ALI）首先且最常发生在脓毒症患者中。龙胆苦苷（GPS）主要来源于龙胆科植物，属于裂环环烯醚萜苷类。三萜糖苷具有多种生物活性，包括肝脏保护、血糖和胆固醇水平管理以及抗炎和抗肿瘤作用。然而，目前，GPS 对脓毒症诱导的 ALI 的抗炎作用的生化基础和机制尚不清楚。在本研究中，我们建立了盲肠结扎和穿刺诱导的脓毒症 ALI 大鼠模型。这使我们能够观察 GPS 治疗的效果，GPS 治疗在整体动物和分子水平上均显著减轻了炎症反应（TNF-α、IL-1 和 IL-6）、氮应激、氧化应激和 ALI 的严重程度。此外，GPS 通过调节 BEAS-2B 中的炎症反应和细胞凋亡来改善 LPS 诱导的 ALI。本研究为 GPS 治疗脓毒症诱导的 ALI 提供了理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/70852eafb35c/CRJ2024-1068326.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/3ae3467a35b8/CRJ2024-1068326.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/319ac018c204/CRJ2024-1068326.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/91c2acce75f6/CRJ2024-1068326.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/37a2a79b4c74/CRJ2024-1068326.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/50101cd8ce87/CRJ2024-1068326.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/70852eafb35c/CRJ2024-1068326.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/3ae3467a35b8/CRJ2024-1068326.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/319ac018c204/CRJ2024-1068326.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/91c2acce75f6/CRJ2024-1068326.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/37a2a79b4c74/CRJ2024-1068326.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/50101cd8ce87/CRJ2024-1068326.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef1f/11392574/70852eafb35c/CRJ2024-1068326.006.jpg

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本文引用的文献

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BMC Pharmacol Toxicol. 2023 Nov 20;24(1):63. doi: 10.1186/s40360-023-00698-3.
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Gentiopicroside alleviated epileptogenesis in immature rats through inactivation of NLRP3 inflammasome by inhibiting P2X7R expression.龙胆苦苷通过抑制P2X7R表达使NLRP3炎性小体失活，从而减轻幼龄大鼠的癫痫发生。
Int J Dev Neurosci. 2023 Feb;83(1):53-66. doi: 10.1002/jdn.10237. Epub 2022 Nov 29.
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Gentiopicroside alleviates cardiac inflammation and fibrosis in T2DM rats through targeting Smad3 phosphorylation.
龙胆苦苷通过靶向 Smad3 磷酸化缓解 T2DM 大鼠心脏炎症和纤维化。
Phytomedicine. 2022 Nov;106:154389. doi: 10.1016/j.phymed.2022.154389. Epub 2022 Aug 12.
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YAP1 alleviates sepsis-induced acute lung injury inhibiting ferritinophagy-mediated ferroptosis.YAP1 通过抑制铁蛋白自噬介导的铁死亡缓解脓毒症诱导的急性肺损伤。
Front Immunol. 2022 Aug 1;13:884362. doi: 10.3389/fimmu.2022.884362. eCollection 2022.
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