• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

小鼠固有激活型浆细胞样树突状细胞的淋巴样起源。

Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice.

机构信息

Department of Chemical Engineering, The University of Texas at Austin, Austin, United States.

Department of Biomedical Engineering, and Livestrong Cancer Institutes, The University of Texas at Austin, Austin, United States.

出版信息

Elife. 2024 Sep 13;13:RP96394. doi: 10.7554/eLife.96394.

DOI:10.7554/eLife.96394
PMID:39269281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11398865/
Abstract

We identified a novel mouse plasmacytoid dendritic cell (pDC) lineage derived from the common lymphoid progenitors (CLPs) that is dependent on expression of . These CLP-derived pDCs, which we refer to as 'B-pDCs', have a unique gene expression profile that includes hallmark B cell genes, normally not expressed in conventional pDCs. Despite expressing most classical pDC markers such as SIGLEC-H and PDCA1, B-pDCs lack IFN-α secretion, exhibiting a distinct inflammatory profile. Functionally, B-pDCs induce T cell proliferation more robustly than canonical pDCs following Toll-like receptor 9 (TLR9) engagement. B-pDCs, along with another homogeneous subpopulation of myeloid-derived pDCs, display elevated levels of the cell surface receptor tyrosine kinase AXL, mirroring human AXL transitional DCs in function and transcriptional profile. Murine B-pDCs therefore represent a phenotypically and functionally distinct CLP-derived DC lineage specialized in T cell activation and previously not described in mice.

摘要

我们鉴定出一种新型的小鼠浆细胞样树突状细胞 (pDC) 谱系，它源自共同淋巴样前体 (CLP)，并依赖于 的表达。我们将这些 CLP 衍生的 pDC 称为“B-pDC”，它们具有独特的基因表达谱，包括通常不在常规 pDC 中表达的标志性 B 细胞基因。尽管表达大多数经典的 pDC 标志物，如 SIGLEC-H 和 PDCA1，但 B-pDC 缺乏 IFN-α 分泌，表现出独特的炎症表型。功能上，B-pDC 在 TLR9 （ Toll-like receptor 9 ） 结合后，比经典 pDC 更能强烈地诱导 T 细胞增殖。B-pDC 与另一种同质的髓样来源的 pDC 亚群一起，表现出高水平的细胞表面受体酪氨酸激酶 AXL，反映了人类 AXL 过渡性 DC 在功能和转录谱上的相似性。因此，小鼠 B-pDC 代表一种表型和功能上明显不同的源自 CLP 的 DC 谱系，专门用于 T 细胞激活，以前在小鼠中未被描述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/d9f2c23b15b3/elife-96394-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/09899f5c5078/elife-96394-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/e19cc24631e3/elife-96394-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/66984010c9e9/elife-96394-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/518722ee9a19/elife-96394-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/3fe5f4dbb8e2/elife-96394-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/3030f10c924f/elife-96394-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/c2c63448ba8d/elife-96394-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/b4bc7dbfc8f1/elife-96394-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/ca3edbf7aafa/elife-96394-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/d0746f804a1e/elife-96394-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/d9f2c23b15b3/elife-96394-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/09899f5c5078/elife-96394-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/e19cc24631e3/elife-96394-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/66984010c9e9/elife-96394-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/518722ee9a19/elife-96394-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/3fe5f4dbb8e2/elife-96394-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/3030f10c924f/elife-96394-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/c2c63448ba8d/elife-96394-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/b4bc7dbfc8f1/elife-96394-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/ca3edbf7aafa/elife-96394-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/d0746f804a1e/elife-96394-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/11398865/d9f2c23b15b3/elife-96394-fig5.jpg

相似文献

1
Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice.小鼠固有激活型浆细胞样树突状细胞的淋巴样起源。
Elife. 2024 Sep 13;13:RP96394. doi: 10.7554/eLife.96394.
2
The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.人类树突状细胞的发育程序独立于传统的髓系和淋巴系途径运行。
Blood. 2007 Nov 15;110(10):3591-660. doi: 10.1182/blood-2007-02-071613. Epub 2007 Jul 30.
3
Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors.不同来源的浆细胞样树突状细胞具有不同的特征和功能：淋巴祖细胞与髓系祖细胞的研究
J Immunol. 2005 Dec 1;175(11):7281-7. doi: 10.4049/jimmunol.175.11.7281.
4
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.I 型干扰素-Flt3 配体轴增强了普通淋巴祖细胞向浆细胞样树突状细胞的发育。
J Exp Med. 2013 Nov 18;210(12):2515-22. doi: 10.1084/jem.20130536. Epub 2013 Oct 21.
5
Plasmacytoid dendritic cells develop from Ly6D lymphoid progenitors distinct from the myeloid lineage.浆细胞样树突状细胞来源于不同于髓系的 Ly6D 淋巴祖细胞。
Nat Immunol. 2019 Jul;20(7):852-864. doi: 10.1038/s41590-019-0420-3. Epub 2019 Jun 18.
6
Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand.通过Flt3配体从普通淋巴祖细胞高效生成浆细胞样树突状细胞。
PLoS One. 2015 Aug 11;10(8):e0135217. doi: 10.1371/journal.pone.0135217. eCollection 2015.
7
Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset.与母细胞样浆细胞样树突状细胞肿瘤相关的人类BDCA2+CD123+CD56+树突状细胞（DCs）代表一种独特的髓样DC亚群。
Protein Cell. 2015 Apr;6(4):297-306. doi: 10.1007/s13238-015-0140-x. Epub 2015 Mar 18.
8
Contribution of Dendritic Cell Subsets to T Cell-Dependent Responses in Mice.树突状细胞亚群对小鼠依赖 T 细胞应答的贡献。
J Immunol. 2022 Mar 1;208(5):1066-1075. doi: 10.4049/jimmunol.2100242. Epub 2022 Feb 9.
9
Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells.趋同分化：髓系和淋巴系途径向鼠浆细胞样树突状细胞分化。
Blood. 2013 Jan 3;121(1):11-9. doi: 10.1182/blood-2012-02-413336. Epub 2012 Oct 10.
10
What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity.是什么造就了浆细胞样树突状细胞：理解浆细胞样树突状细胞发育和异质性的最新进展。
Front Immunol. 2019 May 29;10:1222. doi: 10.3389/fimmu.2019.01222. eCollection 2019.

引用本文的文献

1
Advancing the understanding and management of blastic plasmacytoid dendritic cell neoplasm: Insights from recent case studies.提高对母细胞性浆细胞样树突状细胞肿瘤的认识与管理：近期病例研究的见解
World J Clin Cases. 2024 Nov 6;12(31):6441-6446. doi: 10.12998/wjcc.v12.i31.6441.
2
GSK-3β in Dendritic Cells Exerts Opposite Functions in Regulating Cross-Priming and Memory CD8 T Cell Responses Independent of β-Catenin.树突状细胞中的糖原合成酶激酶3β在调节交叉启动和记忆性CD8 T细胞反应中发挥相反作用，且不依赖于β-连环蛋白。
Vaccines (Basel). 2024 Sep 10;12(9):1037. doi: 10.3390/vaccines12091037.

本文引用的文献

1
CD5L is a canonical component of circulatory IgM.CD5L 是循环 IgM 的规范组成部分。
Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2311265120. doi: 10.1073/pnas.2311265120. Epub 2023 Dec 6.
2
A bifurcation concept for B-lymphoid/plasmacytoid dendritic cells with largely fluctuating transcriptome dynamics.一种具有高度波动转录组动态的B淋巴细胞/浆细胞样树突状细胞的分叉概念。
Cell Rep. 2022 Aug 30;40(9):111260. doi: 10.1016/j.celrep.2022.111260.
3
Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment.
Axl 介导呼吸道合胞病毒感染的耐药性，与细胞附着无关。
Am J Respir Cell Mol Biol. 2022 Aug;67(2):227-240. doi: 10.1165/rcmb.2021-0362OC.
4
Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells.克隆谱系追踪揭示了传统树突状细胞和浆细胞样树突状细胞的共同起源。
Immunity. 2022 Mar 8;55(3):405-422.e11. doi: 10.1016/j.immuni.2022.01.016. Epub 2022 Feb 17.
5
CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments.CIPR：一个基于网络的 R/shiny 应用程序和 R 包，用于注释单细胞 RNA 测序实验中的细胞簇。
BMC Bioinformatics. 2020 May 15;21(1):191. doi: 10.1186/s12859-020-3538-2.
6
Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population.整合跨物种分析鉴定出保守的过渡性树突状细胞群体。
Cell Rep. 2019 Dec 10;29(11):3736-3750.e8. doi: 10.1016/j.celrep.2019.11.042.
7
Plasmacytoid dendritic cells develop from Ly6D lymphoid progenitors distinct from the myeloid lineage.浆细胞样树突状细胞来源于不同于髓系的 Ly6D 淋巴祖细胞。
Nat Immunol. 2019 Jul;20(7):852-864. doi: 10.1038/s41590-019-0420-3. Epub 2019 Jun 18.
8
PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells.PAGA：通过对单细胞进行拓扑保持映射，实现了聚类和轨迹推断的图抽象。
Genome Biol. 2019 Mar 19;20(1):59. doi: 10.1186/s13059-019-1663-x.
9
The single-cell transcriptional landscape of mammalian organogenesis.哺乳动物器官发生的单细胞转录组图谱。
Nature. 2019 Feb;566(7745):496-502. doi: 10.1038/s41586-019-0969-x. Epub 2019 Feb 20.
10
Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells.不同祖系细胞为浆细胞样树突状细胞的异质性做出贡献。
Nat Immunol. 2018 Jul;19(7):711-722. doi: 10.1038/s41590-018-0136-9. Epub 2018 Jun 20.