Sonnhoff M, Hermann R-M, Aust K, Knöchelmann A-C, Nitsche M, Ernst B, Christiansen H, Blach R-M
Department of Radiotherapy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Center for Radiotherapy and Radiooncology Bremen and Westerstede, 26655, Westerstede, Germany.
Strahlenther Onkol. 2025 Feb;201(2):185-190. doi: 10.1007/s00066-024-02295-7. Epub 2024 Sep 13.
Breathing instruction and exercises and a time gap between training and planning CT scans (pCT) is recommended as part of deep inspiration breath-hold (DIBH) assisted radiotherapy (RT). However, this is associated with additional time expenditure.
In two of the authors' treatment centers (TC), patient training took place before the planning CT of DIBH-assisted therapy. In TC 1, a further appointment was made with a minimum interval of 2 days to perform the planning CT. At TC 2, the planning CT was performed immediately after the first patient instruction. A retrospective evaluation of the clinical parameters of the therapy was carried out to investigate the relevance of the time gap between DIBH exercises and pCT.
A total of 72 patients were included, 35 of whom were treated in TC 1 and 37 in TC 2. In TC 1, an average interval of ~4 days was observed between patient training and planning CT, while in TC 2, training and CT were performed immediately after each other. No significant differences in radiation dose exposure of the lung on the treated side, the whole lung, or the heart were found between the two centers. Furthermore, there was no significant difference in the application of the daily RT fraction. The requirement for daily positioning checks was also the same at both treatment centers.
This study does not show any advantages for a time gap between instruction/training and pCT. Skipping the time break does not deteriorate any clinically relevant endpoints.
呼吸指导与练习以及训练与计划CT扫描（pCT）之间的时间间隔被推荐作为深吸气屏气（DIBH）辅助放疗（RT）的一部分。然而，这会带来额外的时间消耗。
在两位作者所在的两个治疗中心（TC），患者训练在DIBH辅助治疗的计划CT之前进行。在治疗中心1，安排了至少间隔2天的进一步预约来进行计划CT。在治疗中心2，计划CT在首次患者指导后立即进行。对治疗的临床参数进行回顾性评估，以研究DIBH练习与pCT之间时间间隔的相关性。
共纳入72例患者，其中35例在治疗中心1接受治疗，37例在治疗中心2接受治疗。在治疗中心1，患者训练与计划CT之间的平均间隔约为4天，而在治疗中心2，训练和CT紧接着依次进行。两个中心之间在患侧肺、全肺或心脏的辐射剂量暴露方面未发现显著差异。此外，每日放疗分次的应用也没有显著差异。两个治疗中心每日定位检查的要求也相同。
本研究未显示出指导/训练与pCT之间的时间间隔有任何优势。省略时间间隔不会使任何临床相关终点恶化。
