Children's Hospital of Fudan University, Shanghai, China.
McMaster University, Hamilton, Ontario, Canada.
P R Health Sci J. 2024 Sep;43(3):119-124.
Primary ciliary dyskinesia (PCD) is a respiratory disorder that impairs mucociliary clearance, leading to decreased lung function. Conventional chest physiotherapy (CCP) is the traditional airway clearance technique (ACT) and is considered a standard treatment for PCD patients. This systematic review investigated whether device supported ACTs are better alternatives for improving lung function and/or quality of life in PCD, compared with CCP.
The OVID Medline, PubMed, CINAHL, and Cochrane databases were searched. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed, and the Grading of Recommendations, Assessment, Development, and Evaluation approach was used to aggregate the data. This systematic review has been registered on the International Prospective Register of Systematic Reviews website.
Of the 389 citations that resulted from our literature search, 2 randomized crossover trials that included a total of 54 patients were analyzed. The certainty of the aggregated study evidence was very low. No difference was identified between device-supported ACTs and CCP in terms of forced vital capacity and forced expiratory volume in 1 second in PCD patients aged 6 to 20 years.
Device-supported ACTs could be considered alternative treatment options to replace CCP. High quality research is required to confirm this result.
原发性纤毛运动障碍（PCD）是一种呼吸系统疾病，会损害黏液纤毛清除功能，导致肺功能下降。传统的胸部物理疗法（CCP）是传统的气道清除技术（ACT），被认为是 PCD 患者的标准治疗方法。本系统评价旨在研究与 CCP 相比，设备支持的 ACT 是否是改善 PCD 患者肺功能和/或生活质量的更好替代方法。
对 OVID Medline、PubMed、CINAHL 和 Cochrane 数据库进行了检索。遵循系统评价和荟萃分析的首选报告项目指南，并使用推荐评估、制定与评价方法对数据进行汇总。本系统评价已在国际前瞻性系统评价登记处网站上注册。
从文献检索中得到的 389 条引文，分析了 2 项随机交叉试验，共纳入 54 例患者。汇总研究证据的确定性非常低。在 6 至 20 岁的 PCD 患者中，设备支持的 ACT 与 CCP 在用力肺活量和 1 秒用力呼气量方面没有差异。
设备支持的 ACT 可以被认为是替代 CCP 的治疗选择。需要高质量的研究来证实这一结果。
