Kowaluk E A, Roberts M S, Polack A E
J Pharm Sci. 1985 Jun;74(6):625-33. doi: 10.1002/jps.2600740609.
The time course of sorption of diazepam and nitroglycerin from aqueous solutions into plastic materials has been represented by the diffusion and compartmental models for a variety of storage conditions. The diffusion model seemed to be the more satisfactory model in respect to both description and prediction of the drug uptake for all conditions. The compartment model appeared to be useful for describing the drug uptake at earlier times, giving a satisfactory fit to the data and reliable final parameter estimates. However, that model was not able to describe the loss as equilibrium was approached or accurately predict the disappearance profiles for these solutes with alterations in solution volume or infusion bag size. Approximations of the diffusion model gave parameter estimates consistent with those obtained by nonlinear regression using the full equations.
在各种储存条件下，地西泮和硝酸甘油从水溶液吸附到塑料材料中的时间过程已通过扩散模型和房室模型来表示。就所有条件下药物摄取的描述和预测而言，扩散模型似乎是更令人满意的模型。房室模型似乎有助于描述早期的药物摄取，能很好地拟合数据并给出可靠的最终参数估计值。然而，当接近平衡时，该模型无法描述药物损失情况，也无法准确预测这些溶质在溶液体积或输液袋尺寸改变时的消失曲线。扩散模型的近似值给出的参数估计与使用完整方程通过非线性回归得到的参数估计一致。
