Winsnes M, Jeppsson R, Sjöberg B
Acta Anaesthesiol Scand. 1981 Apr;25(2):93-6. doi: 10.1111/j.1399-6576.1981.tb01615.x.
The adsorption of diazepam to infusion sets and plastic syringes was studied. Infusion solutions consisting of diazepam injection (Valium) in glucose 5.5%, or diazepam emulsion in a lipid emulsion (Intralipid 10%) were infused through two different infusion sets (Transcodan L-74 and Cutter IL). It was found that, when an infusion solution with a low diazepam concentration (0.04 mg/ml) was infused slowly (4 ml/h), the diazepam adsorption was more than 80%. At a higher diazepam concentration (0.1 mg/ml) and increased infusion rate (20ml/h) the adsorption decreased. Diazepam injection in glucose 5.5% was adsorbed to a higher degree (40-75%) than diazepam emulsion in glucose 5.5% (15-35%). When diazepam emulsion was diluted with the lipid emulsion, no diazepam adsorption to the infusion set occurred at this concentration and infusion rate. No significant difference between the two infusion sets could be found. The miscibility of diazepam emulsion with glucose 5.5%, glucose 10%, or sodium chloride 0.9% was examined. Diazepam emulsion proved to be miscible with glucose 5.5% and glucose 10%, but sodium chloride should not be used to dilute diazepam emulsion. The effect on the diazepam concentration of storing diazepam injection and diazepam emulsion in plastic syringes for up to 4h was also studied. It was found that the diazepam concentration remained unchanged during this time.
研究了地西泮在输液器和塑料注射器上的吸附情况。将含有地西泮注射液（安定）的5.5%葡萄糖溶液或脂质乳剂（英脱利匹特10%）中的地西泮乳剂通过两种不同的输液器（Transcodan L - 74和Cutter IL）进行输注。结果发现，当以低地西泮浓度（0.04毫克/毫升）的输液溶液缓慢输注（4毫升/小时）时，地西泮的吸附率超过80%。在地西泮浓度较高（0.1毫克/毫升）且输注速率增加（20毫升/小时）时，吸附率下降。5.5%葡萄糖中的地西泮注射液比5.5%葡萄糖中的地西泮乳剂吸附程度更高（40 - 75%）。当地西泮乳剂用脂质乳剂稀释时，在此浓度和输注速率下未发生地西泮对输液器的吸附。未发现两种输液器之间有显著差异。检查了地西泮乳剂与5.5%葡萄糖、10%葡萄糖或0.9%氯化钠的混溶性。结果证明地西泮乳剂可与5.5%葡萄糖和10%葡萄糖混溶，但不应使用氯化钠来稀释地西泮乳剂。还研究了将地西泮注射液和地西泮乳剂在塑料注射器中储存长达4小时对其浓度的影响。结果发现在此期间地西泮浓度保持不变。
