Luoma H, Nyman A, Toivonen A, Söderholm S, Nuuja T, Kantero R L, Hassinen M L, Jokela M, Nummikoski P, Ranta H, Thesleff I
Scand J Dent Res. 1979 Jun;87(3):197-207. doi: 10.1111/j.1600-0722.1979.tb00673.x.
Mentally handicapped children, aged 5--15 years and living in institutions, received fluoride supplement in several sugar products of their diet; in candies, marmalades, jams, fruit juices and in sweet desserts corresponding to 10 mg F as NaF per kg of the sugar (sucrose or glucose) of each product. To two of the four daily candies was also added a NaHCO3 + KH2PO4 mixture (mole ratio 9.8/l, resp.) to substitute for 2.5% of the sugar of the candy. The control children received the respective products without the additives. After stepwise exclusions of subjects for various reasons, e.g. for the absence of permanent teeth, low initial caries activity, strong medication, Down's syndrome, etc., the mean DMFS-increment in the remaining 43 control subjects was 4.5 and in the 41 test subjects 2.6 lesions/100 surfaces at risk, i.e. 42% reduction. Caries arrestment had occurred in these test subjects after the first year, while in the respective controls it was continuously increasing. Among numerous oral and body parameters studied, only surface enamel fluoride in primary teeth was increased by the fluoride supplements and urinary phosphate and calcium excretion decreased.
5至15岁生活在福利院的智障儿童在其饮食中的多种含糖产品中补充了氟化物；在糖果、果酱、果汁和甜点心等产品中，每千克糖（蔗糖或葡萄糖）对应补充10毫克氟化钠形式的氟。在每日四颗糖果中的两颗还添加了碳酸氢钠和磷酸二氢钾混合物（摩尔比分别为9.8/1），以替代糖果中2.5%的糖。对照组儿童食用不含添加剂的相应产品。在因各种原因逐步排除研究对象后，例如没有恒牙、初始龋活性低、用药量大、唐氏综合征等，其余43名对照对象的平均DMFS增加值为4.5，41名试验对象为2.6个病变/100个易感牙面，即减少了42%。这些试验对象在第一年出现了龋齿停止进展的情况，而相应的对照组龋齿情况则持续加重。在所研究的众多口腔和身体参数中，只有乳牙表面釉质氟含量因补充氟化物而增加，尿磷和钙排泄量减少。
