School of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Biomed Pharmacother. 2024 Oct;179:117436. doi: 10.1016/j.biopha.2024.117436. Epub 2024 Sep 12.
The occurrence and development of tumors are closely associated with abnormalities in the immune system's structure and function, with tumor immunotherapy being intricately linked to the tumor microenvironment (TME). Early studies on lymphocytes within the TME primarily concentrated on T cells. However, as research has advanced, the multifaceted roles of tumor-infiltrating B cells (TIL-Bs) in tumor immunity, encompassing both anti-tumor and pro-tumor effects, have garnered increasing attention. This paper explored the composition of the TME and the biological characteristics of TIL-Bs, investigating the dual roles within the TME to offer new insights and strategies for tumor immunotherapy.
肿瘤的发生和发展与免疫系统结构和功能的异常密切相关，肿瘤免疫治疗与肿瘤微环境（TME）密切相关。早期对 TME 中的淋巴细胞的研究主要集中在 T 细胞上。然而，随着研究的进展，肿瘤浸润 B 细胞（TIL-Bs）在肿瘤免疫中的多方面作用，包括抗肿瘤和促肿瘤作用，引起了越来越多的关注。本文探讨了 TME 的组成和 TIL-Bs 的生物学特性，研究了 TME 中的双重作用，为肿瘤免疫治疗提供了新的见解和策略。
