Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancer Cell. 2024 Oct 14;42(10):1631-1636. doi: 10.1016/j.ccell.2024.08.016. Epub 2024 Sep 12.
Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. Given the histologic and molecular heterogeneity of OC, we will focus on high-grade serous carcinoma (HGSC). Here, we provide a critical and more holistic view of the evidence supporting various routes of metastasis, including peritoneal, hematogenous, lymphatic, and nerve-related. Understanding the underlying mechanisms is necessary to improve treatment strategies for this challenging disease.
从历史上看，人们认为卵巢癌（OC）通过表面到表面的扩散转移，但最近的研究进展对转移扩散途径有了新的认识。鉴于 OC 的组织学和分子异质性，我们将重点关注高级别浆液性癌（HGSC）。在这里，我们提供了一个关键的、更全面的视角，以支持各种转移途径的证据，包括腹膜、血行、淋巴和神经相关途径。了解潜在的机制对于改善这种具有挑战性的疾病的治疗策略是必要的。
