Lin Xiaorui, Li Zihan, Huang Yibao, Li Yinuo, Li Yuting, Zhang Ling, Wu Mingfu
National Clinical Research Center for Obstetrical and Gynecological Diseases, Department of Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan 430030, People's Republic of China.
Int J Nanomedicine. 2025 May 26;20:6721-6742. doi: 10.2147/IJN.S527023. eCollection 2025.
Gynecological cancers represent one of the leading causes of death in women and pose a critical global health challenge. While surgery and chemotherapy remain the first-line therapies for gynecological cancers, the persistently high morbidity and mortality rates have driven the urgent exploration of novel theranostic strategies. In recent years, polymer nanoparticles (PNPs) have gained increasing attention in the diagnosis and treatment of cancer due to their superior targeting ability and delivery efficiency. This review provides an overview of PNPs and their role in tumor diagnosis and treatment, with a strategic focus on their utility in gynecological cancers. It covers drug delivery, imaging, combination therapy, and theranostic integration in gynecological cancers, and summarizes the composition, principles and characteristics of diverse polymers and their cargoes. Furthermore, this work highlights innovative applications of PNPs in gynecological cancers management, spanning chemotherapy, immunotherapy, PARPi therapy, phototherapy and other therapies. Despite promising preclinical advancements in PNPs, formidable challenges persist in their clinical translation. This review serves as a comprehensive resource for researchers and clinicians aiming to optimize gynecological cancers theranostics as well as accelerate the development and clinical translation of PNPs.
妇科癌症是女性主要死因之一，也是全球重大的健康挑战。虽然手术和化疗仍是妇科癌症的一线治疗方法，但居高不下的发病率和死亡率促使人们迫切探索新的诊疗策略。近年来，聚合物纳米颗粒（PNPs）因其卓越的靶向能力和递送效率，在癌症诊断和治疗中受到越来越多关注。本综述概述了PNPs及其在肿瘤诊断和治疗中的作用，重点探讨其在妇科癌症中的应用。内容涵盖妇科癌症中的药物递送、成像、联合治疗以及诊疗一体化，并总结了不同聚合物及其所载药物的组成、原理和特性。此外，本文还强调了PNPs在妇科癌症管理中的创新应用，包括化疗、免疫治疗、PARPi治疗、光疗等。尽管PNPs在临床前研究中取得了令人鼓舞的进展，但其临床转化仍面临巨大挑战。本综述为旨在优化妇科癌症诊疗以及加速PNPs开发和临床转化的研究人员和临床医生提供了全面的参考资料。
