Department of Public Health, College of Medicine and Health Science, Jigjiga University, P.O.BOX: 1020, Jigjiga, Ethiopia.
Department of Medicine, College of Medicine and Health Science, Jigjiga University, Jigjiga, Ethiopia.
BMC Surg. 2024 Sep 14;24(1):262. doi: 10.1186/s12893-024-02567-0.
Infantile hypertrophic pyloric stenosis (IHPS) is a condition whose etiology is not clear, but it is characterized by progressive hypertrophy of the circular muscles of the pylorus with consequent obstruction of the gastric outflow, mostly in neonates and infants under the age of one year.
To assess the treatment outcome and associated factors of infantile pyloric sphincter stenosis among paediatric patients admitted to HFCSUH and JUSHYRH.
A retrospective patient record review with 78 participants was studied consecutively using a structured questionnaire. The data was processed and analyzed using Epi Info 7 and SPSS version 24. Descriptive analysis was done, and then associated factors to the outcome were assessed using logistic regression analysis. The association's significance was determined using an odds ratio with a 95% confidence interval and a P-value less than 0.05. The study period was from November 1st to 30th, 2022.
The magnitude of unfavorable IHPS was 17.1% with a 95% confidence interval of 16.7-23.9%. Hypokalemia (AOR = 2.3, CI = 3.015-19.54), severe dehydration (AOR = 30.9, CI = 2.89-31.75), and delayed presentation (AOR = 7.37, CI = 2.761-12.08) were independent predictors.
The study found a highly unfavorable treatment outcome with delayed presentation; dehydration and electrolyte disturbance were the main predictors of poor outcome. It is recommended to increase community awareness about non-bilious vomiting in infants and ensure high suspicion among healthcare providers. Moreover, following guidelines to correct fluid and electrolyte disturbances and managing these patients in the pediatric ICU postoperatively.
婴儿肥厚性幽门狭窄（IHPS）是一种病因不明的疾病，但其特征是幽门环形肌进行性肥厚，导致胃流出道受阻，主要发生在新生儿和 1 岁以下婴儿。
评估 HFCSUH 和 JUSHYRH 收治的小儿幽门狭窄患者的治疗结果和相关因素。
采用回顾性病历回顾研究，连续纳入 78 例患者，使用结构化问卷进行研究。使用 Epi Info 7 和 SPSS 版本 24 对数据进行处理和分析。进行描述性分析，然后使用逻辑回归分析评估与结果相关的因素。使用比值比（95%置信区间和 P 值<0.05）来确定关联的显著性。研究期间为 2022 年 11 月 1 日至 30 日。
不利 IHPS 的严重程度为 17.1%，95%置信区间为 16.7-23.9%。低钾血症（AOR=2.3，CI=3.015-19.54）、严重脱水（AOR=30.9，CI=2.89-31.75）和延迟就诊（AOR=7.37，CI=2.761-12.08）是独立的预测因素。
本研究发现就诊延迟的治疗结果不佳；脱水和电解质紊乱是不良结局的主要预测因素。建议提高社区对婴儿非胆汁性呕吐的认识，并确保医疗保健提供者高度怀疑。此外，应遵循指南纠正液体和电解质紊乱，并在小儿 ICU 术后管理这些患者。
