Ferrell Jessica M
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Cancers (Basel). 2024 Aug 23;16(17):2925. doi: 10.3390/cancers16172925.
Circadian rhythms dictate the timing of cellular and organismal physiology to maintain homeostasis. Within the liver and gut, circadian rhythms influence lipid and glucose homeostasis, xenobiotic metabolism, and nutrient absorption. Disruption of this orchestrated timing is known to negatively impact human health and contribute to disease progression, including carcinogenesis. Dysfunctional core clock timing has been identified in malignant growths and may be used as a molecular signature of disease progression. Likewise, the circadian clock and its downstream effectors also represent potential for novel therapeutic targets. Here, the role of circadian rhythms in the pathogenesis of cancers of the liver and gut will be reviewed, and chronotherapy and chronopharmacology will be explored as potential treatment options.
昼夜节律决定细胞和机体生理活动的时间，以维持体内平衡。在肝脏和肠道中，昼夜节律影响脂质和葡萄糖稳态、外源性物质代谢以及营养物质吸收。已知这种精心编排的时间被打乱会对人类健康产生负面影响，并促进疾病进展，包括致癌作用。在恶性肿瘤中已发现核心生物钟时间功能失调，其可用作疾病进展的分子标志。同样，生物钟及其下游效应器也代表了新型治疗靶点的潜力。在此，将综述昼夜节律在肝癌和肠癌发病机制中的作用，并探讨时间治疗和时间药理学作为潜在治疗选择的可能性。
