自由基清除剂对与花生四烯酸级联反应相关的“体内”诱导动脉血栓形成的影响。

The effect of free radical scavengers on "in vivo" induced arterial thrombosis in relation to the arachidonate cascade.

作者信息

Bourgain R H, Deby C, Andries R, Braquet P

出版信息

Prostaglandins Leukot Med. 1985 Jun;18(3):353-8. doi: 10.1016/0262-1746(85)90068-x.

Abstract

Arterial platelet thrombosis induced by topical superfusion with adenosine diphosphate (ADP) is enhanced by tranylcypromine, an inhibitor of prostacyclin-synthetase. This effect is evanescent; indeed continuous superfusion with tranylcypromine results in a decrease of the thrombotic parameter to normal control values within forty minutes. This tachyphylactic-like phenomenon is attributed to the deactivation of cyclooxygenase by free radicals, probably oxygen species generated during the arachidonate cascade. In the presence of free radical scavengers such as uric acid, mannitol or formate the tachyphylactic phenomenon disappears suggesting that cyclooxygenase is no longer deactivated. The regression over time induced by tranylcypromine is computed as a measure for the inactivation of cyclooxygenase.

摘要

用前列环素合成酶抑制剂反苯环丙胺局部灌注诱导的动脉血小板血栓形成，会因反苯环丙胺而增强。这种作用是短暂的；实际上，用反苯环丙胺持续灌注会导致血栓形成参数在40分钟内降至正常对照值。这种速发性耐受样现象归因于自由基（可能是花生四烯酸级联反应过程中产生的氧物种）使环氧化酶失活。在存在尿酸、甘露醇或甲酸等自由基清除剂的情况下，速发性耐受现象消失，这表明环氧化酶不再失活。计算反苯环丙胺随时间引起的消退情况，作为环氧化酶失活的一种度量。