Britton K T, Morgan J, Rivier J, Vale W, Koob G F
Psychopharmacology (Berl). 1985;86(1-2):170-4. doi: 10.1007/BF00431704.
The role of corticotropin-releasing factor (CRF) in mediating the stress response was studied using a behavioral test in which anxiety or conflict influence performance. Rats implanted with intraventricular cannulae were tested in a Geller-Seifter conflict test modified for incremental shock. CRF produced a dose-dependent attenuation of punished and nonpunished responding in the conflict test. Chlordiazepoxide increased punished, but not unpunished, responding and produced a dose-dependent reversal of CRF-induced response suppression. CRF had no effect on tail flick or hot-plate analgesia tests. The results support the hypothesis that CRF produces behavioral effects consistent with "anxiety" or an increased responsiveness to stress.
利用一种行为测试研究促肾上腺皮质激素释放因子（CRF）在介导应激反应中的作用，在该测试中焦虑或冲突会影响行为表现。给植入脑室内插管的大鼠进行改良的Geller-Seifter冲突测试，以施加递增电击。在冲突测试中，CRF使受惩罚和未受惩罚反应呈剂量依赖性减弱。氯氮卓增加受惩罚反应，但不增加未受惩罚反应，并使CRF诱导的反应抑制呈剂量依赖性逆转。CRF对甩尾或热板镇痛测试无影响。这些结果支持以下假设：CRF产生与“焦虑”一致的行为效应或对应激的反应性增加。
