Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-107 Poznan, Poland.
Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, 61-107 Poznan, Poland.
Int J Mol Sci. 2024 Sep 5;25(17):9633. doi: 10.3390/ijms25179633.
In end-stage heart failure, which is characterized by persistent or progressive ventricular dysfunction despite optimal medical therapy, a left ventricular assist device (LVAD) can be beneficial. Congestive heart failure provokes inflammatory and prothrombotic activation. The aim of this study was to evaluate the serum concentration of citrullinated histone 3 (CH3) representing neutrophil extracellular trap (NET) formation in patients referred for LVAD implantation. There were 10 patients with a median age of 61 (57-65) years enrolled in a prospective single-center analysis who underwent LVAD implantation. The CH3 plasma concentration was measured preoperatively and on the 1st and 7th postoperative days, followed by control measurements on the median (Q1-3) 88th (49-143) day. The preoperative CH3 concentration strongly correlated with brain natriuretic peptide (r = 0.879, < 0.001). Significant differences in CH3 serum concentration were observed between pre- and postoperative measurements, including an increase on the first postoperative day ( < 0.001), as well as a decrease on the seventh day ( = 0.016) and in follow-up ( < 0.001). CH3 concentration, as a marker of NET formation, decreases after LVAD implantation.
在终末期心力衰竭中，尽管采用了最佳的药物治疗，但仍存在持续或进行性心室功能障碍，此时左心室辅助装置（LVAD）可能有益。充血性心力衰竭会引发炎症和促血栓形成的激活。本研究旨在评估因 LVAD 植入而接受评估的患者血清中代表中性粒细胞胞外诱捕网（NET）形成的瓜氨酸化组蛋白 3（CH3）的浓度。前瞻性单中心分析纳入了 10 名中位年龄为 61（57-65）岁的患者，这些患者接受了 LVAD 植入。在术前和术后第 1 天和第 7 天测量 CH3 血浆浓度，然后在第 88 天（49-143）中位数（Q1-3）进行对照测量。术前 CH3 浓度与脑钠肽（BNP）呈强相关（r = 0.879，<0.001）。在术前和术后测量中，CH3 血清浓度存在显著差异，包括术后第 1 天增加（<0.001），第 7 天下降（=0.016）和随访时下降（<0.001）。作为 NET 形成的标志物，CH3 浓度在 LVAD 植入后降低。
