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TLR2、-3、-4 和 -8 亚组分析与 HPV 感染宫颈临床表现严重程度的关系。

Subgroup Analysis of TLR2, -3, -4 and -8 in Relation to the Severity of Clinical Manifestations of Cervical HPV Infection.

机构信息

Project Office, Moscow City Hospital 52, 123182 Moscow, Russia.

Clinical Immunology and Allergology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia.

出版信息

Int J Mol Sci. 2024 Sep 8;25(17):9719. doi: 10.3390/ijms25179719.

DOI:10.3390/ijms25179719
PMID:39273663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11395980/
Abstract

We present the findings of assessing the expression levels of extracellular TLR2 and TLR4 and intracellular TLR3 and TLR8 correlating with the severity of clinical manifestations of HPV infection. A total of 199 women took part in a single-center prospective comparative research study on TLR2, TLR3, TLR4 and TLR8 expression in HPV-related cervical lesions. TLRs' mRNA expression was analyzed using real-time reverse transcription polymerase chain reaction (RT-PCR). Our results indicate the potential significance of TLR3, TLR4 and TLR8 in responding to HPV infection and its progression to SILs and CC, highlighting the importance of HPV polyinfection in relation to TLR4 and TLR8.

摘要

我们报告了评估 HPV 感染临床表现严重程度与细胞外 TLR2 和 TLR4 及细胞内 TLR3 和 TLR8 表达水平之间相关性的研究结果。共有 199 名女性参与了一项关于 TLR2、TLR3、TLR4 和 TLR8 在 HPV 相关宫颈病变中表达的单中心前瞻性对比研究。使用实时逆转录聚合酶链反应 (RT-PCR) 分析 TLRs 的 mRNA 表达。我们的结果表明 TLR3、TLR4 和 TLR8 在应对 HPV 感染及其进展为 SILs 和 CC 方面具有潜在意义，强调了 HPV 多感染与 TLR4 和 TLR8 相关的重要性。

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