Giannopapas Vasileios, Smyrni Vassiliki, Kitsos Dimitrios K, Stasi Sophia, Chasiotis Athanasios K, Moschovos Christos, Papagiannopoulou Georgia, Stavrogianni Konstantina, Kosmidou Maria, Bakalidou Daphne, Tzartos John S, Tsivgoulis Georgios, Giannopoulos Sotirios
Second Department of Neurology, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Department of Physical Therapy, University of West Attica, 12243 Egaleo, Greece.
J Clin Med. 2024 Aug 24;13(17):5015. doi: 10.3390/jcm13175015.
Arthritis, particularly osteoarthritis (OA), is a common synovial condition observed in individuals with multiple sclerosis (MS). Despite its high prevalence and significant impact on the quality of life of MS individuals, there is a gap in the current literature regarding the prevalence of OA in this population and its relation to MS pathology. This systematic review and meta-analysis aimed to estimate the prevalence of OA in the MS population and explore potential associations with demographic and MS-specific characteristics. : Adhering to PRISMA guidelines, a systematic search of the MEDLINE PubMed, Scopus and Google Scholar databases was conducted. : Fifteen studies were included in the systematic review and meta-analysis. The aggregated prevalence of OA in the MS population was 27% (95% CI: 15-40%), with substantial heterogeneity (I = 99.9%). Sensitivity analysis, excluding one study, showed a prevalence of 21% (95% CI: 16-28%). The risk ratio of OA in MS versus controls was 1.07 (95% CI: 0.84-1.37), indicating no significant difference. Meta-regression revealed no associations between OA prevalence and age or disease duration in MS patients. : This study reports a 21-27% prevalence of OA in people with MS. Understanding the implications of OA in pain and mobility domains, as well as the challenges in distinguishing OA symptoms from MS manifestations, underscores the need for further research to elucidate the pathophysiological mechanisms and interactions between these conditions. Additional studies are warranted to enhance clinical management and improve outcomes for individuals with MS and co-existing OA.
关节炎，尤其是骨关节炎（OA），是多发性硬化症（MS）患者中常见的滑膜疾病。尽管其在MS患者中患病率很高且对生活质量有重大影响，但目前关于该人群中OA患病率及其与MS病理关系的文献存在空白。本系统评价和荟萃分析旨在估计MS人群中OA的患病率，并探讨其与人口统计学和MS特异性特征的潜在关联。：按照PRISMA指南，对MEDLINE、PubMed、Scopus和谷歌学术数据库进行了系统检索。：15项研究纳入了系统评价和荟萃分析。MS人群中OA的总体患病率为27%（95%CI：15 - 40%），存在显著异质性（I² = 99.9%）。排除一项研究后的敏感性分析显示患病率为21%（95%CI：16 - 28%）。MS患者与对照组相比患OA的风险比为1.07（95%CI：0.84 - 1.37），表明无显著差异。Meta回归显示MS患者中OA患病率与年龄或病程之间无关联。：本研究报告MS患者中OA患病率为21% - 27%。了解OA在疼痛和活动领域的影响，以及区分OA症状与MS表现的挑战，凸显了进一步研究以阐明这些疾病之间病理生理机制和相互作用的必要性。需要更多研究来加强对MS合并OA患者的临床管理并改善其预后。
