Comparative Effects of Neurodynamic Slider and Tensioner Mobilization Techniques on Sympathetic Nervous System Function: A Randomized Controlled Trial.

: To investigate the effect of slider and tensioner neurodynamic techniques (NDTs) on the sympathetic nervous system (SNS) activity, aiming to identify which technique more effectively modulates autonomic responses in asymptomatic individuals. : In this double-blind controlled trial, a total of 90 healthy participants were randomly allocated into three groups: slider, tensioner, and control. Skin conductance (SC) was continuously monitored throughout the entire 20 min experiment, while body temperature and blood pressure were measured pre- and post-intervention. : The SC levels significantly increased in both the slider and tensioner groups compared to the control group during the intervention and end rest period on the left leg (slider vs. control: < 0.001, d = 1.20; tensioner vs. control: < 0.001, d = 1.64) and on the right leg (slider vs. control: < 0.001, d = 1.47; tensioner vs. control: < 0.001, d = 0.73). There were no significant differences between the two NDTs on the left ( < 0.13, d = 0.89) and right legs ( < 1.00, d = 0.36). The body temperature of the slider group showed a significant increase compared to both the control group ( < 0.001, d = 0.95) and the tensioner group ( < 0.001, d = 1.48). There were no significant differences between the groups in systolic ( = 0.95) or diastolic blood pressure ( = 0.06). There were no side-specific effects on SNS activity between the left and right legs ( < 0.019) during all intervention phases. : Significant sympathoexcitatory responses were elicited by both slider and tensioner NDTs in asymptomatic participants, demonstrating their efficacy in modulating the SNS. The differences between the two techniques were not statistically significant; however, the tensioner NDT showed a slightly more pronounced effect, suggesting that the tensioner NDT can be considered superior in terms of overall SNS effect. These findings indicate that both techniques may have the potential to enhance autonomic regulation in clinical practice; however, the tensioner NDT may be more effective. The consistent responses across participants highlight the systemic benefits of NDTs, providing a foundation for further research into their application in symptomatic populations. This study contributes to evidence-based practice by providing baseline data that support the development of theoretical frameworks and aid in clinical decision-making.