Barbuti Margherita, D'Alessandro Giulia, Weiss Francesco, Calderone Alba, Santini Ferruccio, Perugi Giulio, Maremmani Icro
2nd Psychiatry Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Roma 67, 56126 Pisa, Italy.
1st Endocrinology Unit, Department of Clinical and Experimental Medicine, Obesity and Lipodystrophy Research Center, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.
J Clin Med. 2024 Aug 30;13(17):5158. doi: 10.3390/jcm13175158.
: Psychiatric symptoms are highly prevalent in patients with severe obesity, often representing pivotal factors in the development and progression of this condition. This study examines the association between negative emotional dysregulation (NED) and weight loss following bariatric surgery. : Ninety-nine patients were consecutively enrolled at the Obesity Center of the Pisa University Hospital between March 2019 and February 2021, during a routine psychiatric evaluation before bariatric surgery. Psychopathological dimensions were assessed using the Mini-International Neuropsychiatric Interview (MINI), the Reactivity, Intensity, Polarity, and Stability questionnaire in its 40-item version (RIPoSt-40), the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) and the Barratt Impulsiveness Scale (BIS-11). Based on a RIPoSt-40 cut-off score of 70, subjects were divided into two groups: with (NED+) and without (NED-) NED. : NED+ subjects had a higher rate of psychiatric comorbidities and eating disorders than NED- patients. Of the total sample, 76 underwent bariatric surgery, and 65 of them were re-evaluated one-year after surgery. Among them, 10 of 28 NED+ subjects (37.5%) had inadequate weight loss one year after surgery compared to 5 of 37 NED- subjects (13.5%) ( = 0.035, OR 3.55, 95%, C.I. 1.05-12.03). : Our results suggest a significant association between NED and inadequate weight loss at one-year post surgery.
精神症状在重度肥胖患者中高度普遍，往往是这种疾病发生和发展的关键因素。本研究探讨负性情绪调节障碍（NED）与减肥手术后体重减轻之间的关联。2019年3月至2021年2月期间，比萨大学医院肥胖中心在减肥手术前的常规精神评估中连续招募了99名患者。使用迷你国际神经精神访谈（MINI）、40项版本的反应性、强度、极性和稳定性问卷（RIPoSt - 40）、温德 - 赖姆赫尔成人注意力缺陷障碍量表（WRAADDS）和巴拉特冲动量表（BIS - 11）评估精神病理维度。根据RIPoSt - 40临界值70，将受试者分为两组：有NED（NED +）和无NED（NED -）。NED +组受试者的精神共病和饮食失调发生率高于NED -组患者。在总样本中，76人接受了减肥手术，其中65人在术后一年进行了重新评估。其中，28名NED +组受试者中有10人（37.5%）术后一年体重减轻不足，而37名NED -组受试者中有5人（13.5%）（P = 0.035，OR 3.55，95%置信区间1.05 - 12.03）。我们的结果表明，NED与术后一年体重减轻不足之间存在显著关联。
