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结直肠癌的阶段特异性血浆代谢组学特征

Stage-Specific Plasma Metabolomic Profiles in Colorectal Cancer.

作者信息

Ishizaki Tetsuo, Sugimoto Masahiro, Kuboyama Yu, Mazaki Junichi, Kasahara Kenta, Tago Tomoya, Udo Ryutaro, Iwasaki Kenichi, Hayashi Yutaka, Nagakawa Yuichi

机构信息

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku 160-0023, Tokyo, Japan.

Institute of Medical Science, Tokyo Medical University, Shinjuku 160-8402, Tokyo, Japan.

出版信息

J Clin Med. 2024 Sep 2;13(17):5202. doi: 10.3390/jcm13175202.

DOI:10.3390/jcm13175202
PMID:39274416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11396754/
Abstract

: The objective of this study was to investigate the metabolomic profiles of patients with colorectal cancer (CRC) across various stages of the disease. : The plasma samples were obtained from 255 subjects, including patients with CRC in stages I-IV, polyps, and controls. We employed capillary electrophoresis time-of-flight mass spectrometry and liquid chromatography triple quadrupole mass spectrometry to analyze hydrophilic metabolites comprehensively. The data were randomly divided into two groups, and consistent differences observed in both groups were analyzed. : Acetylated polyamines, such as -acetylspermine and , -diacetylspermine, consistently showed elevated concentrations in stage IV compared to stages I-III. Non-acetylated polyamines, including spermine and spermidine, exhibited increasing trends from polyp to stage IV. Other metabolites, such as histidine and o-acetylcarnitine, showed decreasing trends across stages. While acetylated polyamines have been reported as CRC detection markers, our findings suggest that they also possess diagnostic potential for distinguishing stage IV from other stages. : This study showed stage-specific changes in metabolic profiles, including polyamines, of colorectal cancer.

摘要

本研究的目的是调查处于疾病不同阶段的结直肠癌（CRC）患者的代谢组学特征。血浆样本取自255名受试者，包括I-IV期的CRC患者、息肉患者和对照组。我们采用毛细管电泳飞行时间质谱法和液相色谱三重四极杆质谱法全面分析亲水性代谢物。数据被随机分为两组，并对两组中观察到的一致差异进行分析。与I-III期相比，乙酰化多胺，如N1-乙酰精胺和N1,N8-二乙酰精胺，在IV期的浓度持续升高。非乙酰化多胺，包括精胺和亚精胺，从息肉到IV期呈上升趋势。其他代谢物，如组氨酸和O-乙酰肉碱，在各阶段呈下降趋势。虽然乙酰化多胺已被报道为CRC检测标志物，但我们的研究结果表明，它们也具有区分IV期与其他阶段的诊断潜力。本研究显示了结直肠癌代谢谱包括多胺的阶段特异性变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/e4e1c05687fc/jcm-13-05202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/39286812905a/jcm-13-05202-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/b04314667ea0/jcm-13-05202-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/d3608c089f26/jcm-13-05202-g0A3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/8273e0f24b3a/jcm-13-05202-g0A4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/2394870ed96c/jcm-13-05202-g0A5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/3082dc9089cc/jcm-13-05202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/1457ddb223c8/jcm-13-05202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/a9b32c521ce8/jcm-13-05202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/717c48d241b2/jcm-13-05202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/e4e1c05687fc/jcm-13-05202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/39286812905a/jcm-13-05202-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/b04314667ea0/jcm-13-05202-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/d3608c089f26/jcm-13-05202-g0A3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/8273e0f24b3a/jcm-13-05202-g0A4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/2394870ed96c/jcm-13-05202-g0A5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/3082dc9089cc/jcm-13-05202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/1457ddb223c8/jcm-13-05202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/a9b32c521ce8/jcm-13-05202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/717c48d241b2/jcm-13-05202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265b/11396754/e4e1c05687fc/jcm-13-05202-g005.jpg

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