Abu Dail Yaser, Seitz Berthold, Sideroudi Haris, Abdin Alaa Din
Department of Ophthalmology, Saarland University Medical Center, 66421 Homburg, Germany.
J Clin Med. 2024 Sep 8;13(17):5318. doi: 10.3390/jcm13175318.
: To investigate the influence of intraretinal fluid (IRF) on change in retinal nerve fiber layer (RNFL) and retinal ganglion cell layer (RGCL) and thickness in patients with naive neovascular AMD under anti-VEGF treatment. : post hoc analysis. : 97 eyes of 83 patients on continuous therapy with intravitreal anti-vascular endothelial growth factors (anti-VEGF) and a follow-up of 24 months were included. RGCL and RNFL thickness in the perifoveal (-O), parafoveal (PF), and nasal areas and number of injections (IVI) were recorded before the first IVI as well as 1 and 2 years after initiating treatment and compared longitudinally and between groups with and without IRF. : The group with IRF at baseline had a higher RNFL thickness at baseline and showed a significant reduction in RNFL-PF between baseline and first and second follow-ups ( < 0.001) but not between first and second follow-ups. The group without IRF showed no significant reduction in RNFL over time. The presence of IRF was not associated with a reduction in RNFL-O or RNFL-nasal. RGCL thickness decreased significantly in both groups with and without IRF after 2 years. Number of IVIs showed no significant correlation to RNFL or RGCL after stratification for the presence of IRF. : The presence of IRF has a significant influence on RNFL thickness at baseline as well as on its changes over time during anti-VEGF therapy. The preoperative presence of IRF should be considered when comparing changes in RNFL thickness after IVI.
探讨视网膜内液（IRF）对初发新生血管性年龄相关性黄斑变性（AMD）患者接受抗血管内皮生长因子（抗VEGF）治疗时视网膜神经纤维层（RNFL）和视网膜神经节细胞层（RGCL）变化及厚度的影响。方法：事后分析。纳入83例接受玻璃体内抗VEGF持续治疗且随访24个月的患者的97只眼。记录首次玻璃体内注射（IVI）前、开始治疗后1年和2年时黄斑中心凹周围（-O）、旁黄斑区（PF）和鼻侧区域的RGCL和RNFL厚度以及注射次数（IVI），并在纵向以及有和无IRF的组间进行比较。结果：基线时存在IRF的组在基线时RNFL厚度较高，且在基线与第一次和第二次随访之间RNFL - PF显著降低（<0.001），但在第一次和第二次随访之间无显著降低。无IRF的组RNFL随时间无显著降低。IRF的存在与RNFL - O或RNFL - 鼻侧的降低无关。有和无IRF的两组在2年后RGCL厚度均显著降低。分层分析IRF的存在后，IVI次数与RNFL或RGCL无显著相关性。结论：IRF的存在对基线时的RNFL厚度以及抗VEGF治疗期间其随时间的变化有显著影响。在比较IVI后RNFL厚度变化时应考虑术前IRF的存在。
