Department of Ophthalmology, Kangwon National University School of Medicine, Chuncheon, Korea.
Korean J Ophthalmol. 2020 Oct;34(5):404-412. doi: 10.3341/kjo.2020.0013. Epub 2020 Oct 5.
We sought to establish normative ranges of the ganglion cell-inner plexiform layer (GCIPL) thickness using spectral-domain optical coherence tomography in Korean elderly individuals and to identify factors that influence GCIPL thickness.
We conducted a retrospective, observational study of 114 healthy subjects (75 years old or older) who underwent comprehensive ophthalmic examinations at a single institution. GCIPL thickness was measured with the Cirrus spectral-domain optical coherence tomography system and automatic segmentation. Subjects were divided into two age groups: those younger than 80 years and those 80 years or older, respectively. A cross-sectional analysis was adopted to evaluate associations of GCIPL thickness with sex, age, intraocular pressure, optic disc rim area, axial length, spherical equivalent (SE) refractive errors, astigmatism, and body mass index.
The average and minimum GCIPL thicknesses were 80.3 ± 5.6 µm and 76.3 ± 5.9 µm, respectively. The GCIPL thickness was significantly lower in the older group than in the younger group in the inferior, inferonasal, and inferotemporal segments (all p < 0.01). A thinner average GCIPL thickness was strongly associated with increasing age (β = -2.87, p = 0.021) and thinner circumpapillary retinal nerve fiber layer thickness (β = 2.87, p < 0.001) in all segments.
GCIPL thickness decreased with age globally and in all segments, even after 75 years of age. Thinner GCIPL was associated with older age and thinner circumpapillary retinal nerve fiber layer. Age-related changes should be considered when using GCIPL thickness to assess glaucoma and other optic neuropathies characterized by retinal ganglion cell loss.
我们旨在通过频域光相干断层扫描（OCT）为韩国老年人建立正常的神经节细胞-内丛状层（GCIPL）厚度范围，并确定影响 GCIPL 厚度的因素。
我们对在一家机构接受全面眼科检查的 114 名健康受试者（年龄在 75 岁或以上）进行了回顾性、观察性研究。使用 Cirrus 频域 OCT 系统和自动分割测量 GCIPL 厚度。受试者分为两个年龄组：分别为年龄小于 80 岁和年龄 80 岁或以上。采用横断面分析评估 GCIPL 厚度与性别、年龄、眼内压、视盘边缘面积、眼轴长度、等效球镜（SE）屈光不正、散光和体重指数之间的关系。
平均和最小 GCIPL 厚度分别为 80.3±5.6 µm 和 76.3±5.9 µm。下、下鼻侧和下颞侧各节段老年组的 GCIPL 厚度均显著低于年轻组（均 p < 0.01）。平均 GCIPL 厚度较薄与年龄增加呈强相关（β=-2.87，p=0.021），与所有节段的环周视网膜神经纤维层厚度变薄呈强相关（β=2.87，p < 0.001）。
GCIPL 厚度在全球范围内和所有节段随年龄增长而降低，即使在 75 岁以上也是如此。GCIPL 较薄与年龄较大和环周视网膜神经纤维层较薄相关。在使用 GCIPL 厚度评估以视网膜神经节细胞丢失为特征的青光眼和其他视神经病变时，应考虑年龄相关的变化。
