Konrádová V, Vávrová V, Sulová J
Respiration. 1985;48(1):50-7. doi: 10.1159/000194798.
The effect of the application of a single oral dose of 100 mg of three mucolytic agents (N-acetylcysteine, carbocysteine and Na-2-mercaptoethane sulphonate) on the ultrastructure of the tracheal epithelium of healthy rabbits was studied. Due to the function of oral mucolytics the goblet cells were overstimulated and injured. Na-2-mercaptoethane sulphonate was the least irritating substance. Acetylcysteine produced the most pronounced injury of the goblet cells, followed by rapid differentiation of these cells. Oral administration of all mucolytics studied caused local impairment of mucus flow in the airways.
研究了单次口服100毫克三种黏液溶解剂（N - 乙酰半胱氨酸、羧甲司坦和2 - 巯基乙烷磺酸钠）对健康兔气管上皮超微结构的影响。由于口服黏液溶解剂的作用，杯状细胞受到过度刺激和损伤。2 - 巯基乙烷磺酸钠是刺激性最小的物质。乙酰半胱氨酸对杯状细胞造成的损伤最为明显，随后这些细胞迅速分化。所研究的所有黏液溶解剂口服给药均导致气道内黏液流动的局部受损。
