Risack L E, Vandevelde M E, Gobert J G
Resuscitation. 1978;6(1):9-20. doi: 10.1016/0300-9572(78)90031-x.
The disintegrating effect of three reducing thiol derivatives: [sodium mercaptoethane sulphonate (Mesna), N-acetyl-L-cysteine (NAC) and dithio-1,4-threitol (DTT)] was investigated in vitro upon blood clots formed in the absence or in the presence of tracheobronchial secretions and compared with the effect of iso-osmotic saline solution. The amounts of haemoglobin released from the clots after 30 min incubation and the initial rates of haemoglobin release were compared for the different products at different concentrations. All three reducing agents showed some ability to disintegrate mixed clots to an extent depending on their concentration. After 30 min incubation, statistical analysis showed a highly significant difference in favour of Mesna at the three concentrations used, i.e. 0.1, 1.0 and 10 mmol/1. The initial rate of haemoglobin release in presence of Mesna was at all concentrations significantly higher than that of NAC or DTT. The effects on normal blood clots were much less pronounced. The effectiveness of Mesna in splitting up mixed blood and mucus clots in the management of patients who had inhaled blood is discussed.
巯基乙烷磺酸钠（美司钠）、N-乙酰-L-半胱氨酸（NAC）和二硫苏糖醇（DTT）在体外对在无气管支气管分泌物或有气管支气管分泌物存在的情况下形成的血凝块的溶解作用，并与等渗盐溶液的作用进行了比较。比较了不同浓度的不同产品在孵育30分钟后从血凝块中释放的血红蛋白量以及血红蛋白释放的初始速率。所有三种还原剂都表现出一定程度的溶解混合血凝块的能力，这取决于它们的浓度。孵育30分钟后，统计分析表明，在所使用的三种浓度（即0.1、1.0和10 mmol/L）下，美司钠具有极显著的优势。在所有浓度下，美司钠存在时血红蛋白的初始释放速率均显著高于NAC或DTT。对正常血凝块的影响则不太明显。讨论了美司钠在治疗吸入血液的患者中分解混合血液和黏液血凝块的有效性。
