School Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, China.
Molecules. 2024 Aug 31;29(17):4134. doi: 10.3390/molecules29174134.
With the increasing global incidence and mortality rates of cancer, the development of novel anti-tumor drugs has become particularly urgent. D. Don, a perennial herb belonging to the genus Scutellaria in the family Lamiaceae, has aroused extensive attention for its medicinal value in recent years. This article presents an exhaustive review of the flavonoid, diterpene, and other chemical constituents harbored within , delving into the intricate mechanisms by which these compounds orchestrate their anti-tumor effects via diverse biological pathways. Remarkably, these compounds distinguish themselves through their capability to regulate cellular signaling, inhibit cancer cell proliferation, trigger apoptosis, disrupt angiogenesis, and bolster immune responses. These anti-tumor effects are achieved through strategic modulation of pivotal signaling cascades, particularly the PI3K/Akt/mTOR, MAPK, and NFκB pathways. In addition, this article also summarizes the clinical applications of in tumor treatment, especially its potential in alleviating the side effects of radiotherapy and chemotherapy and improving patients' quality of life. In conclusion, this review comprehensively summarizes and analyzes the chemical constituents, anti-tumor mechanisms, and clinical applications of , with the aim of systematically reviewing the existing research results and exploring potential future research directions.
随着癌症在全球的发病率和死亡率不断上升，新型抗肿瘤药物的开发变得尤为迫切。丹参，唇形科黄芩属多年生草本植物，近年来因其药用价值而引起广泛关注。本文对丹参中的黄酮类、二萜类等化学成分进行了全面综述，深入探讨了这些化合物通过多种生物途径发挥抗肿瘤作用的复杂机制。值得注意的是，这些化合物通过调节细胞信号、抑制癌细胞增殖、诱导细胞凋亡、破坏血管生成和增强免疫反应来发挥其抗肿瘤作用。这些抗肿瘤作用是通过对关键信号通路的策略性调节来实现的，特别是 PI3K/Akt/mTOR、MAPK 和 NFκB 通路。此外，本文还总结了丹参在肿瘤治疗中的临床应用，特别是其在减轻放化疗副作用和提高患者生活质量方面的潜力。总之，本文全面总结和分析了丹参的化学成分、抗肿瘤机制和临床应用，旨在系统回顾现有研究成果并探索潜在的未来研究方向。
