Institute of Chinese Materia Madica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
J Ethnopharmacol. 2020 May 23;254:112260. doi: 10.1016/j.jep.2019.112260. Epub 2019 Sep 29.
Scutellaria barbata D. Don (S. barbata) is a well-known perennial herb that is used in traditional Chinese and Korean medicine. In China, it is known as Ban Zhi Lian, while in Korea, it is known as Banjiryun. In the Traditional Chinese Medicine (TCM) system, S. barbata has heat-clearing and detoxifying properties (Qingre Jiedu in Chinese).
To provide a systematic review on current multifaceted understanding of S. barbata, with particular emphasis on the correlation between its traditional applications and pharmacological activities.
All available S. barbata-related information from internet databases, including PubMed, Science Direct, Elsevier, China National Knowledge Internet, and Google Scholar (up to October 2018) were searched. Additional information was gathered from classical books on Chinese Herbals, Chinese Pharmacopoeia, and so on.
In the TCM system, S. barbata is mainly prescribed for its heat-clearing and detoxifying effects. More than 203 compounds have been isolated and identified from this herb, with neo-clerodane diterpenoids and flavonoids as the main compounds. Most neo-clerodanes have been demonstrated to have cytotoxic effects against different cancer cell types in vitro. The S. barbata extracts exhibited anti-inflammatory, anti-microbial, antitumor, and other pharmacological activities. To add, flavonoids, including wogonin, baicalein, apigenin, naringenin, and scutellarin, were identified as the key to quality control.
The heat-clearing effects of S. barbata could be attributed to its anti-inflammatory and hepatoprotective activities, whereas its detoxifying effects might be due to the anti-microbial functions of neo-clerodane diterpenoids and flavones. S. barbata may display anti-tumor effects and through active ingredient analysis, neo-clerodane diterpenoids are suggested to be its representative compounds. Overall, many pre-clinical studies have been conducted but very little concrete evidences are available on its specific effects, which are of therapeutic relevance.
黄芩（Scutellaria barbata D. Don）是一种广为人知的多年生草本植物，在中国和韩国传统医学中被使用。在中国，它被称为板兰根，而在韩国，它被称为板蓝根。在中医（TCM）系统中，黄芩具有清热解毒的特性（中文为清热解毒）。
提供对黄芩多方面理解的系统综述，特别强调其传统应用与药理学活性之间的相关性。
从互联网数据库（包括 PubMed、Science Direct、Elsevier、中国国家知识网和 Google Scholar）中搜索所有可用的黄芩相关信息，检索时间截至 2018 年 10 月。此外，还从中草药经典著作、中国药典等中收集了其他信息。
在 TCM 系统中，黄芩主要用于清热解毒。从该植物中已分离鉴定出 203 多种化合物，主要化合物为新蛇麻烷二萜和黄酮类化合物。大多数新蛇麻烷已被证明在体外对不同类型的癌细胞具有细胞毒性作用。黄芩提取物具有抗炎、抗菌、抗肿瘤等多种药理活性。此外，黄酮类化合物，包括黄芩素、黄芩苷、芹菜素、柚皮苷和野黄芩苷，被认为是质量控制的关键。
黄芩的清热作用可能归因于其抗炎和保肝活性，而其解毒作用可能归因于新蛇麻烷二萜和黄酮类的抗菌作用。黄芩可能具有抗肿瘤作用，通过活性成分分析，新蛇麻烷二萜类化合物被认为是其代表性化合物。总的来说，已经进行了许多临床前研究，但关于其具体疗效的具体证据很少。
