Khalfen E Sh, Shtern S V
Ter Arkh. 1985;57(5):79-84.
The results of intracoronary thrombolytic therapy with avelysine given to 21 patients with acute myocardial infarction are described. Intracoronary thrombolysis was performed on the average 5 h and 30 min after myocardial infarction onset. Recanalization of the coronary artery was attained in 16 patients, with no lethal outcomes. One patient died out of the 5, in whom attempts to recanalize the artery ended in failure. Recanalization of the coronary arteries led to improvement of left ventricle function and appreciably accelerated the time-course of the enzymatic shifts (KPK and LDH) in blood of myocardial infarction patients. After successful recanalization of the coronary artery the disease in myocardial infarction patients took a far milder course as compared to those who did receive intracoronary thrombolytic therapy.
本文描述了对21例急性心肌梗死患者进行冠状动脉内注射阿韦赖氨酸溶栓治疗的结果。冠状动脉内溶栓平均在心肌梗死发作后5小时30分钟进行。16例患者实现了冠状动脉再通，且无致命后果。5例再通尝试失败的患者中有1例死亡。冠状动脉再通改善了左心室功能，并显著加速了心肌梗死患者血液中酶变化（肌酸磷酸激酶和乳酸脱氢酶）的进程。与未接受冠状动脉内溶栓治疗的患者相比，冠状动脉成功再通后，心肌梗死患者的病情发展要温和得多。
