van Brussel B L, Hendriks D, Relik-van Wely L, el Gamal M I, Ernst J M, Plokker H W
Ned Tijdschr Geneeskd. 1989 Feb 18;133(7):358-62.
In 285 patients intracoronary fibrinolytic agents were administered 300 times during the acute phase of a myocardial infarction. The results and the complications of this therapy, as administered in a community hospital, did not differ from those obtained in a big randomized study performed by the Interuniversity Cardiological Institute of The Netherlands. Recanalization of a completely occluded coronary artery was obtained in 79% of the cases. Only 8.3% of the patients needed blood transfusion because of blood loss via the puncture in the femoral artery. No intracranial bleeding occurred. Actuarial total survival after 12 months was 90.5%. The incidence of recurrent myocardial infarction after successful intracoronary fibrinolytic therapy appears rather high; therefore, in some patient categories further therapy may be considered such as percutaneous transluminal coronary angioplasty or aortocoronary bypass surgery.
在285例患者中，在心肌梗死急性期进行了300次冠状动脉内溶栓治疗。在一家社区医院进行的这种治疗的结果和并发症，与荷兰大学间心脏病学研究所进行的一项大型随机研究的结果并无差异。79%的病例实现了完全闭塞冠状动脉的再通。仅有8.3%的患者因股动脉穿刺失血而需要输血。未发生颅内出血。12个月时的精算总生存率为90.5%。冠状动脉内溶栓治疗成功后复发性心肌梗死的发生率似乎相当高；因此，对于某些患者类别，可能需要考虑进一步治疗，如经皮冠状动脉腔内血管成形术或主动脉冠状动脉旁路移植术。
