Nutrition and Dietetics School, Faculty of Medical Sciences, University of Cuenca, Cuenca 010204, Ecuador.
Pharmacology and Nutritional Sciences Interdisciplinary Research Group, Faculty of Medical Sciences, University of Cuenca, Cuenca 010204, Ecuador.
Molecules. 2024 Sep 5;29(17):4210. doi: 10.3390/molecules29174210.
The therapeutic properties of turmeric essential oil have been extensively documented in both preclinical and clinical studies. Research indicates that its primary active compounds are promising candidates for addressing a wide range of pathologies, exhibiting anticancer, anti-inflammation, antioxidant, cardiovascular, hypoglycemic, dermatological, hepatoprotective, neurological, antiparasitic, antiviral, insecticidal, antifungal, and antivenom activities. While numerous compounds possess similar potential applications, the isolated active constituents of turmeric essential oil stand out due to their unique pharmacological profiles and absence of toxicity. This literature review meticulously compiles and analyzes the bioactivities of these constituents, emphasizing their molecular mechanisms of action, reported pharmacological effects, and potential therapeutic applications. The aim of this review is to provide a comprehensive synthesis of currently available clinical and preclinical findings related to individual turmeric essential oil compounds, while also identifying critical knowledge gaps. By summarizing these findings, this work encourages further research into the isolated compounds from turmeric oil as viable drug candidates, ultimately contributing to the development of innovative therapeutic strategies.
姜黄精油的治疗特性在临床前和临床研究中都有广泛的记载。研究表明，其主要活性化合物是解决多种病理的有前途的候选物，具有抗癌、抗炎、抗氧化、心血管、降血糖、皮肤病、肝保护、神经保护、抗寄生虫、抗病毒、杀虫、抗真菌和抗蛇毒活性。虽然许多化合物具有相似的潜在应用，但姜黄精油的分离活性成分因其独特的药理学特征和无毒而脱颖而出。本文献综述精心汇编和分析了这些成分的生物活性，强调了它们的作用机制、已报道的药理作用和潜在的治疗应用。本综述的目的是提供与姜黄精油个别化合物相关的现有临床前和临床研究结果的综合综述，同时确定关键的知识空白。通过总结这些发现，这项工作鼓励对姜黄精油中的分离化合物进行进一步研究，作为可行的药物候选物，最终为创新的治疗策略做出贡献。
