Children's Hospital of Soochow University, China.
Department of Cardiology, The First Affiliated Hospital of Soochow University, China.
Biomed Pharmacother. 2024 Oct;179:117416. doi: 10.1016/j.biopha.2024.117416. Epub 2024 Sep 13.
Podocan, a small leucine-rich repeat protein, is expressed in HIV-associated nephropathy, the cardiovascular system, and smooth muscle. Studies have linked PODN and PODNL to cancers such as osteosarcoma, glioma, and stomach cancer. Research has primarily focused on podocan's role in renal podocytes, injured smooth muscle cells, and various tumor cells. Bioinformatics studies have examined the role of PODN as a biomarker in tumors. Our research summarizes the modulatory role of podocan in smooth muscle and tumor proliferation through its suppression of cell proliferation and promotion of cell differentiation via various signaling pathways, including Wnt/β-catenin, TGF-β, and Akt/mTOR. We aim to provide a comprehensive overview of PODN's involvement in smooth muscle, cardiovascular system, and tumors by integrating current and past research. This review aims to enhance understanding and inform in the diagnosis, prognosis, and treatment of various diseases.
足细胞蛋白聚糖（Podocan）是一种富含亮氨酸的小蛋白，在 HIV 相关性肾病、心血管系统和平滑肌中表达。研究表明 PODN 和 PODNL 与骨肉瘤、神经胶质瘤和胃癌等癌症有关。研究主要集中在足细胞蛋白聚糖在肾脏足细胞、受损平滑肌细胞和各种肿瘤细胞中的作用。生物信息学研究已经研究了 PODN 作为肿瘤生物标志物的作用。我们的研究通过 Wnt/β-catenin、TGF-β 和 Akt/mTOR 等各种信号通路，总结了足细胞蛋白聚糖通过抑制细胞增殖和促进细胞分化来调节平滑肌和肿瘤增殖的调节作用。我们旨在通过整合当前和过去的研究，全面概述足细胞蛋白聚糖在平滑肌、心血管系统和肿瘤中的作用。本综述旨在增强对各种疾病的诊断、预后和治疗的理解和信息。
