Lessing J B, Michowitz M, Baratz M
Acta Obstet Gynecol Scand. 1985;64(4):345-7. doi: 10.3109/00016348509155145.
A case is presented of a 12-month-old female infant, with sexual precocity due to a Granulosa-Theca cell tumor which presented with vaginal bleeding, breast development and public hair growth. The 17 beta-estradiol levels prior to operation were 300 pg/ml. Levels of gonadotropins were undetectable. Postoperative estradiol levels were measured and found to be 10 pg/ml. This tumor is very rate in infants, and there have been only four previously reported cases in children under 2 years of age.
本文报告一例12个月大的女婴，因颗粒-卵泡膜细胞瘤出现性早熟，表现为阴道出血、乳房发育和阴毛生长。术前17β-雌二醇水平为300 pg/ml，促性腺激素水平未检测到。术后测量雌二醇水平，发现为10 pg/ml。这种肿瘤在婴儿中非常罕见，之前2岁以下儿童中仅报告过4例。
