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Exploring FNDC4 as a biomarker for prognosis and immunotherapy response in lung adenocarcinoma.

作者信息

Xu Shengshan, Lu Zhuming

机构信息

Department of Thoracic Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China.

出版信息

Asian J Surg. 2024 Sep 13. doi: 10.1016/j.asjsur.2024.09.054.

DOI:10.1016/j.asjsur.2024.09.054
PMID:39277471
Abstract
摘要

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Exploring FNDC4 as a biomarker for prognosis and immunotherapy response in lung adenocarcinoma.探索纤连蛋白结构域包含蛋白4(FNDC4)作为肺腺癌预后和免疫治疗反应的生物标志物。
Asian J Surg. 2024 Sep 13. doi: 10.1016/j.asjsur.2024.09.054.
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Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth.FNDC4的过表达通过促进细胞凋亡和抑制细胞生长来抑制卵巢癌进展。
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Prognostic value of transcriptional expression of fibronectin type III domain-containing 4 (FNDC4) in head and neck carcinoma patients treated with chemoradiotherapy.FNDC4 转录表达对头颈癌患者放化疗预后的价值。
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Construction and validation of a T cell proliferation regulator-related signature for predicting prognosis and immunotherapy response in lung adenocarcinoma.构建并验证 T 细胞增殖调节剂相关标志物用于预测肺腺癌患者的预后和免疫治疗反应。
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Fibronectin type III domain containing 4 alleviates myocardial ischemia/reperfusion injury via the Nrf2-dependent antioxidant pathway.纤维连接蛋白 III 型结构域包含 4 通过 Nrf2 依赖性抗氧化途径减轻心肌缺血/再灌注损伤。
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FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.FNDC4在巨噬细胞上作为一种抗炎因子发挥作用,并改善小鼠的结肠炎。
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Fibronectin Type III Domain Containing 4 attenuates hyperlipidemia-induced insulin resistance via suppression of inflammation and ER stress through HO-1 expression in adipocytes.纤连蛋白结构域蛋白 4 通过脂肪细胞中 HO-1 的表达抑制炎症和内质网应激来减轻高脂血症诱导的胰岛素抵抗。
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FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-B Activation and CXCL10 Expression.FNDC4 通过抑制 NF-B 激活和 CXCL10 表达抑制 RANKL 诱导的破骨细胞形成。
Biomed Res Int. 2018 May 30;2018:3936257. doi: 10.1155/2018/3936257. eCollection 2018.

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Front Pharmacol. 2025 May 20;16:1569644. doi: 10.3389/fphar.2025.1569644. eCollection 2025.
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