调节抗氧化酶对氧磷酶-1 以预防心血管疾病。
Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases.
机构信息
Course Superior of Technology in Radiology, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Department of Basic Life Sciences, Universidade Federal de Juiz de Fora, Governador Valadares, MG, Brazil.
出版信息
Nutr Metab Cardiovasc Dis. 2024 Dec;34(12):2611-2622. doi: 10.1016/j.numecd.2024.04.005. Epub 2024 Apr 13.
AIM
The enzyme paraoxonase 1 (PON1) bound to high-density lipoprotein has received special attention for its protective role against stress-mediated damage and use as a potential regulatory target in atherosclerosis and related vascular diseases.
DATA SYNTHESIS
We present an overview of the literature on PON1 activity and mRNA levels by investigating its modulation for clinical translations. Specifically, the expression of PON1 and its regulated activity can be modified in different ways with natural substances, drugs, and lifestyle factors thar affect the development of atherosclerosis.
CONCLUSIONS
The endothelial contribution of PON1 to overcome differences considering an individual's disease development risk is supported by polymorphism interaction data and the susceptibility to modify PON1 responses in chronic events composed by biological and environmental factors.
目的
与高密度脂蛋白结合的酶对氧磷酶 1（PON1）因其在应激介导损伤中的保护作用以及作为动脉粥样硬化和相关血管疾病的潜在调节靶点而受到特别关注。
数据综合
我们通过研究其对临床转化的调节作用，对 PON1 活性和 mRNA 水平的文献进行了综述。具体来说，PON1 的表达及其调节活性可以通过天然物质、药物和生活方式因素以不同的方式进行修饰，这些因素会影响动脉粥样硬化的发展。
结论
PON1 的内皮贡献有助于克服个体疾病发展风险的差异，这一观点得到了多态性相互作用数据的支持，并且表明 PON1 对慢性生物和环境因素组成的事件的反应具有可修饰性。
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