Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, No. 168-2, Tongzipo Road, Yuelu District, Changsha, Hunan 410000, China.
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, No. 168-2, Tongzipo Road, Yuelu District, Changsha, Hunan 410000, China; Hunan Provincial Key Laboratory of Clinical Epidemiology, Central South University, No. 168-2, Tongzipo Road, Yuelu District, Changsha, Hunan 410000, China.
Nutr Metab Cardiovasc Dis. 2024 Dec;34(12):2779-2788. doi: 10.1016/j.numecd.2024.08.004. Epub 2024 Aug 8.
Previous observational studies have investigated the association between coffee consumption and single cardiometabolic disease. Yet, the extent to which coffee might confer health advantages to individuals with a singular cardiometabolic disease remains unclear. This study aimed to further investigate the association of coffee consumption and the onset and progression from single cardiometabolic disease to cardiometabolic multimorbidity (CMM).
This prospective cohort study included 185,112 participants from the UK Biobank who were enrolled between 2006 and 2010 and followed up until 2020. Coffee consumption was collected using a 24-h dietary questionnaire. CMM was defined as the coexistence of at least two cardiometabolic diseases, including type 2 diabetes (T2D), coronary heart disease (CHD) and stroke. Cox proportional hazards and multi-state models estimated the associations between coffee consumption and CMM. During a median follow-up of 11.4 years, 1585 participants developed CMM. Compared with nonconsumers, coffee consumers had lower risks for the transitions from baseline to single cardiometabolic disease, with the respective lowest hazard ratios and 95% confidence intervals (CIs) for the transitions from baseline to T2D, CHD and stroke after multivariable adjustment being 0.79 (CI, 0.72-0.87), 0.91 (CI, 0.86-0.97) and 0.87 (CI, 0.78-0.96). Coffee consumption resulted in a significant reduction in the risk of the transitions from CHD and stroke to CMM, with the lowest estimates were 0.56 (CI, 0.43-0.73) and 0.60 (CI, 0.43-0.83). Similar associations were observed in unsweetened coffee. Sugar-sweetened coffee was associated with some transitions at low levels of consumption. The associations between artificially sweetened coffee and CMM were less consistent.
Coffee consumption was associated with lower risk for almost all transition phases of CMM development and consistent findings were observed with unsweetened coffee.
先前的观察性研究已经调查了咖啡消费与单一心血管代谢疾病之间的关联。然而，咖啡对患有单一心血管代谢疾病的个体带来的健康益处程度仍不清楚。本研究旨在进一步探讨咖啡消费与单一心血管代谢疾病向心血管代谢多病（CMM）的发生和进展之间的关联。
这项前瞻性队列研究纳入了来自英国生物库的 185112 名参与者，他们于 2006 年至 2010 年期间入组，并随访至 2020 年。使用 24 小时膳食问卷收集咖啡消费情况。CMM 定义为至少两种心血管代谢疾病的共存，包括 2 型糖尿病（T2D）、冠心病（CHD）和中风。Cox 比例风险和多状态模型估计了咖啡消费与 CMM 之间的关联。在中位随访 11.4 年期间，1585 名参与者发生了 CMM。与非消费者相比，咖啡消费者发生从基线到单一心血管代谢疾病的转变的风险较低，经多变量调整后，从基线到 T2D、CHD 和中风的转变的最低风险比和 95%置信区间（CI）分别为 0.79（CI，0.72-0.87）、0.91（CI，0.86-0.97）和 0.87（CI，0.78-0.96）。咖啡消费显著降低了从 CHD 和中风到 CMM 的转变风险，最低估计值分别为 0.56（CI，0.43-0.73）和 0.60（CI，0.43-0.83）。在未加糖咖啡中观察到类似的关联。加糖咖啡在低消费水平与某些转变有关。人工甜味剂咖啡与 CMM 之间的关联不太一致。
咖啡消费与 CMM 发展的几乎所有转变阶段的风险降低相关，并且在未加糖咖啡中观察到一致的发现。
