Gotman J, Marciani M G
Ann Neurol. 1985 Jun;17(6):597-603. doi: 10.1002/ana.410170612.
We investigated the relationships among the electroencephalographic spiking rate, drug levels, and seizure occurrence in 44 patients with focal epilepsy. Seizure occurrence was continuously monitored by personnel or videorecording and spiking rate was quantified by an automatic detection method. Results indicate that drug levels do not influence spiking rate, and spiking rate does not change before seizures but increases markedly after them, particularly secondarily generalized seizures. This increase can last several days and is observed during wakefulness and sleep. High or low spiking rates do not influence the occurrence of seizures. We suggest that interictal spikes may passively reflect damage to the brain, a damage which is worsened by further seizures. Spikes may not be directly related to seizure generation.
我们研究了44例局灶性癫痫患者的脑电图棘波发生率、药物水平与癫痫发作之间的关系。癫痫发作情况由专人持续监测或通过录像记录，棘波发生率采用自动检测方法进行量化。结果表明，药物水平不影响棘波发生率，棘波发生率在癫痫发作前无变化，但在发作后显著增加，尤其是继发全面性发作。这种增加可持续数天，在清醒和睡眠期间均可观察到。高或低的棘波发生率并不影响癫痫发作的发生。我们认为，发作间期棘波可能被动反映大脑损伤，这种损伤会因进一步的癫痫发作而加重。棘波可能与癫痫发作的产生无直接关系。
