Duko Bereket, Mengistu Tesfaye S, Stacey David, Moran Lisa J, Tessema Gizachew, Pereira Gavin, Bedaso Asres, Gebremedhin Amanuel Tesfay, Alati Rosa, Ayonrinde Oyekoya T, Benyamin Beben, Lee S Hong, Hyppönen Elina
Australian Centre for Precision Health, Unit of Clinical & Health Sciences, University of South Australia, Adelaide, SA 5000, Australia; Curtin School of Population Health, Curtin University, Kent St, Bentley, Perth, WA 6102, Australia; South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
Australian Centre for Precision Health, Unit of Clinical & Health Sciences, University of South Australia, Adelaide, SA 5000, Australia; School of Public Health, Faculty of Medicine, The University of Queensland, Herston Queensland, Australia.
Psychiatry Res. 2024 Dec;342:116149. doi: 10.1016/j.psychres.2024.116149. Epub 2024 Aug 15.
Maternal adiposity (overweight or obesity) has been associated with adverse perinatal outcomes, although the potential risks of long-term neuropsychiatric and behavioral outcomes in the offspring remain unclear. Using the PRISMA guidelines, we searched PubMed, EMBASE, Scopus, and Web of Science to identify studies on maternal adiposity and offspring neuropsychiatric outcomes. Inverse variance-weighted random-effects meta-analyses were used to pool effect estimates with 95 % confidence intervals (95 % CIs) from adjusted odds ratios (OR) and hazard ratios (HR). Estimates were computed separately for preconception and pregnancy maternal overweight and obesity, with outcomes stratified by the type of neuropsychiatric outcome. In our meta-analyses of 42 epidemiological studies involving 3,680,937 mother-offspring pairs, we found increased risks of ADHD [OR=1.57, 95 % CI: 1.42-1.74], autism spectrum disorder [OR=1.42, 95 % CI: 1.22-1.65], conduct disorder [OR=1.16, 95 % CI: 1.00-1.35], Psychotic disorder [HR=1.61, 95 % CI: 1.41-1.83], externalizing behaviors [OR=1.30, 95 % CI: 1.07-1.56] and peer relationship problems [OR=1.25, 95 % CI: 1.04-1.27] in the offspring of preconception obese mothers. Similar increased risks were found in the offspring of preconception overweight mothers and those exposed to maternal adiposity during pregnancy. However, no association was found with offspring mood, anxiety, personality, eating, sleep disorders or prosocial problems. Preconception weight management may mitigate such adverse effects in the offspring.
母亲肥胖（超重或肥胖）与不良围产期结局有关，尽管后代长期神经精神和行为结局的潜在风险尚不清楚。我们使用PRISMA指南，检索了PubMed、EMBASE、Scopus和Web of Science，以确定关于母亲肥胖与后代神经精神结局的研究。采用逆方差加权随机效应荟萃分析，汇总来自调整后的优势比（OR）和风险比（HR）的效应估计值及95%置信区间（95%CI）。分别计算孕前和孕期母亲超重及肥胖的效应估计值，并按神经精神结局类型分层。在我们对42项涉及3,680,937对母婴的流行病学研究的荟萃分析中，我们发现孕前肥胖母亲的后代患多动症[OR=1.57，95%CI：1.42-1.74]、自闭症谱系障碍[OR=1.42，95%CI：1.
