The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong, China.
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing, China.
Autoimmun Rev. 2024 Nov;23(11):103640. doi: 10.1016/j.autrev.2024.103640. Epub 2024 Sep 13.
Ferroptosis is a form of regulated cell death that relies on iron and exhibits unique characteristics, including disrupted iron balance, reduced antioxidant defenses, and abnormal lipid peroxidation. Recent research suggests that ferroptosis is associated with the onset and progression of autoimmune disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). However, the precise effects and molecular mechanisms remain incompletely understood. This article presents an overview of how ferroptosis mechanisms contribute to the development and advancement of autoimmune diseases, as well as the involvement of various immune cells in linking ferroptosis to autoimmune conditions. It also explores potential drug targets within the ferroptosis pathway and recent advancements in therapeutic approaches aimed at preventing and treating autoimmune diseases by targeting ferroptosis. Lastly, the article discusses the challenges and opportunities in utilizing ferroptosis as a potential therapeutic avenue for autoimmune disorders.
铁死亡是一种依赖于铁的受调控的细胞死亡形式，具有独特的特征，包括铁平衡失调、抗氧化防御降低和异常脂质过氧化。最近的研究表明，铁死亡与自身免疫性疾病的发生和进展有关，如系统性红斑狼疮 (SLE)、类风湿性关节炎 (RA)、炎症性肠病 (IBD) 和多发性硬化症 (MS)。然而，其确切的作用和分子机制尚不完全清楚。本文综述了铁死亡机制如何促进自身免疫性疾病的发展和进展，以及各种免疫细胞如何将铁死亡与自身免疫状态联系起来。还探讨了铁死亡途径中的潜在药物靶点以及最近在通过靶向铁死亡来预防和治疗自身免疫性疾病方面的治疗方法的进展。最后，文章讨论了将铁死亡作为治疗自身免疫性疾病的一种潜在治疗途径所面临的挑战和机遇。
