College of Traditional Chinese Medicine, Inner Mongolia Medical University, Huhhot, Inner Mongolia, China.
Front Immunol. 2024 Sep 24;15:1455607. doi: 10.3389/fimmu.2024.1455607. eCollection 2024.
Rheumatoid arthritis (RA) is a common autoimmune disease characterized primarily by persistent synovial inflammation and joint destruction. In recent years, ferroptosis, as a novel form of cell death, has garnered widespread attention due to its critical role in various diseases. This review explores the potential mechanisms of ferroptosis in RA and its relationship with the pathogenesis of RA, systematically analyzing the regulatory role of ferroptosis in synovial cells, chondrocytes, and immune cells. We emphasize the evaluation of ferroptosis-related pathways and their potential as therapeutic targets, including the development and application of inhibitors and activators. Although ferroptosis shows some promise in RA treatment, its dual role and safety issues in clinical application still require in-depth study. Future research should focus on elucidating the specific mechanisms of ferroptosis in RA pathology and developing more effective and safer therapeutic strategies to provide new treatment options for RA patients.
类风湿关节炎（RA）是一种常见的自身免疫性疾病，主要特征为持续性滑膜炎症和关节破坏。近年来，铁死亡作为一种新型的细胞死亡形式，因其在各种疾病中的关键作用而受到广泛关注。本综述探讨了铁死亡在 RA 中的潜在机制及其与 RA 发病机制的关系，系统分析了铁死亡在滑膜细胞、软骨细胞和免疫细胞中的调节作用。我们强调了评估铁死亡相关途径及其作为治疗靶点的潜力，包括抑制剂和激活剂的开发和应用。尽管铁死亡在 RA 治疗中显示出一定的前景，但在临床应用中其双重作用和安全性问题仍需要深入研究。未来的研究应侧重于阐明铁死亡在 RA 病理中的具体机制，并开发更有效和更安全的治疗策略，为 RA 患者提供新的治疗选择。
