Camilleri J P, Phat V N, Bruneval P, Tricottet V, Balaton A, Fiessinger J N, Cormier J M
Arch Pathol Lab Med. 1985 Sep;109(9):833-7.
Histologic, transmission, and scanning electron microscopic observations were made of 26 biopsy specimens from patent polytetrafluoroethylene grafts that had been implanted as arterial bypasses for up to 60 months. The results showed the rarity of host connective tissue ingrowth, the absence of neovascularization, and the limited neointimal proliferation. The defect of staining for factor VIII-related antigen by immunohistochemistry confirmed the absence of true endothelial cells at a distance from the anastomoses. Under electron microscopy the thin neointimal layer consisted mainly of fibrin, platelets, blood cells, and cellular debris. Even in prostheses implanted for the longest periods, mature collagen and elastin were not found. Tubular microfibrils (9- to 12-nm thick) could be observed. The source of such microfibrils, probably glycoproteins, remains under investigation.
对26份取自已植入作为动脉搭桥使用长达60个月的聚四氟乙烯人工血管的活检标本进行了组织学、透射电子显微镜及扫描电子显微镜观察。结果显示宿主结缔组织长入少见、无新生血管形成且内膜增生有限。免疫组织化学检测中因子VIII相关抗原染色缺失证实距吻合口一定距离处无真正的内皮细胞。电子显微镜下，薄的内膜层主要由纤维蛋白、血小板、血细胞及细胞碎片组成。即便在植入时间最长的人工血管中，也未发现成熟的胶原和弹性蛋白。可观察到管状微原纤维（9至12纳米厚）。此类微原纤维的来源可能为糖蛋白，仍在研究中。
