Physics Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt.
Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.
BMC Biotechnol. 2024 Sep 15;24(1):61. doi: 10.1186/s12896-024-00889-8.
Nanoporous aluminum metal-organic framework (Al-MOF) was synthesized via solvothermal methods and employed as a carrier matrix for in vitro drug delivery of Umbelliferon (Um). The encapsulated Um was gradually released over seven days at 37 °C, using simulated body fluid phosphate-buffered saline (PBS) at pH 7.4 as the release medium. The drug release profile suggests the potential of Al-MOF nanoparticles as effective drug delivery carriers. Structural and chemical analyses of Um-loaded Al-MOF nanoparticles (Um-Al MOF) were conducted using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffractometry (XRD), and ultraviolet-visible (UV-Vis) spectroscopy. Thermal gravimetric analysis (TGA) was employed to investigate the thermal stability of the Al-MOF nanoparticles, while Transmission Electron Microscopy (TEM) was utilized to assess their morphological features. Um-Al MOF nanoparticles demonstrated notable antioxidant and anti-inflammatory properties compared to Um and Al-MOF nanoparticles individually. Moreover, they exhibited significant enhancement in wound healing in an earthworm model. These findings underscore the potential of Al-MOF nanoparticles as a promising drug delivery system, necessitating further investigations to explore their clinical applicability.
介孔铝基金属有机框架（Al-MOF）通过溶剂热法合成，并用作伞形酮（Um）体外药物输送的载体基质。在 37°C 下，使用模拟体液磷酸盐缓冲盐水（PBS）作为释放介质，封装的 Um 在七天内逐渐释放。药物释放曲线表明 Al-MOF 纳米粒子作为有效药物输送载体的潜力。使用傅里叶变换红外（FTIR）光谱、X 射线衍射（XRD）和紫外可见（UV-Vis）光谱对载有 Um 的 Al-MOF 纳米粒子（Um-Al MOF）进行结构和化学分析。热重分析（TGA）用于研究 Al-MOF 纳米粒子的热稳定性，而透射电子显微镜（TEM）用于评估其形态特征。与 Um 和 Al-MOF 纳米粒子单独相比，Um-Al MOF 纳米粒子表现出显著的抗氧化和抗炎特性。此外，它们在蚯蚓模型中显著增强了伤口愈合。这些发现强调了 Al-MOF 纳米粒子作为有前途的药物输送系统的潜力，需要进一步研究探索其临床应用。
