Kumar Davinder, Mundlia Jyoti, Yadav Shiv Kumar, Yadav Deepika, Aggarwal Navidha, Chopra Hitesh, Kumar Virender, Kamal Mohammad Amjad
College of Pharmacy, Pt BD Sharma University of Health Sciences, Rohtak 124001, India.
B.S. Anangpuria Institute of Pharmacy, Faridabad, Haryana 121004, India.
Curr Pharm Des. 2025;31(6):461-483. doi: 10.2174/0113816128303910240713180835.
Various ailments have been treated with pineapple ( (L.) Merr.) throughout medicinal history. Pineapple and its bioactive compound bromelain possess health-promoting benefits. Detailed information on the chemotherapeutic activities of pineapple and its bioactive compound bromelain is provided in this review, which analyses the current literature regarding their therapeutic potential in cancer. Research on disease models in cell cultures is the focus of much of the existing research. Several studies have demonstrated the benefits of pineapple extract and bromelain for in vitro and in vivo cancer models. Preliminary animal model results show promise, but they must be translated into the clinical setting. Research on these compounds represents a promising future direction and may be well-tolerated.
在整个医学史上，菠萝（凤梨（L.）梅里尔）已被用于治疗各种疾病。菠萝及其生物活性化合物菠萝蛋白酶具有促进健康的益处。本综述提供了关于菠萝及其生物活性化合物菠萝蛋白酶化疗活性的详细信息，分析了当前有关它们在癌症治疗潜力的文献。细胞培养疾病模型的研究是现有许多研究的重点。多项研究已证明菠萝提取物和菠萝蛋白酶对体外和体内癌症模型有益。初步动物模型结果显示出前景，但必须转化到临床环境中。对这些化合物的研究代表了一个有前途的未来方向，并且可能耐受性良好。
