Depta Filip, Olejárová Ingrid, Rybár Dušan, Murín Pavol, Švajdler Marián, Grendel Tomáš
Department of Critical Care, East Slovak Institute for Cardiovascular Diseases, Košice, Slovakia.
Department of Critical Care, National Institute of Cardiovascular Diseases, Bratislava, Slovakia.
Tex Heart Inst J. 2024 Sep 16;51(2). doi: 10.14503/THIJ-24-8431.
Myocarditis is a potentially life-threatening inflammatory disease of the myocardium, often resulting from infectious and immune-mediated responses. Clinical presentation in severe cases often results in a devastating illness requiring extracorporeal membrane oxygenation support as a result of cardiogenic shock. Although endomyocardial biopsy is still considered the gold standard for diagnosis, it often reveals nonspecific lymphocytic infiltration. Because the precise cause is usually unknown, the initial treatment typically involves immunosuppression and frequent assessment of myocardial contractility. This report presents 3 rare cases of autoimmune diseases (polymyositis, immunoglobulin G4-related disease, and systemic lupus erythematosus) that require extracorporeal membrane oxygenation support as a result of fulminant myocarditis, including their follow-up periods.
心肌炎是一种潜在威胁生命的心肌炎症性疾病，通常由感染和免疫介导反应引起。严重病例的临床表现常导致一种毁灭性疾病，因心源性休克而需要体外膜肺氧合支持。尽管心内膜心肌活检仍被认为是诊断的金标准，但它通常显示非特异性淋巴细胞浸润。由于确切病因通常不明，初始治疗通常包括免疫抑制和频繁评估心肌收缩力。本报告介绍了3例罕见的自身免疫性疾病（多发性肌炎、免疫球蛋白G4相关疾病和系统性红斑狼疮），这些疾病因暴发性心肌炎而需要体外膜肺氧合支持，包括它们的随访期。
