Caglayan Ilkin Seda Can, Çelik Nurullah, Bolat Serkan
Department of Obstetrics and Gynecology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey.
Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Clin Endocrinol (Oxf). 2025 Apr;102(4):413-420. doi: 10.1111/cen.15132. Epub 2024 Sep 16.
Adipose tissue has an important endocrine function by secreting a variety of hormones known as adipokines, such as Visfatin, Omentin-1 and Chemerin. On the other hand, these hormones are also secreted from places other than fatty tissues in the girl's genital system. The goal of this study was to demonstrate the secretory status of adipokines in patients with central precocious puberty (CPP) and their utility in the diagnosis of precocious puberty.
A total of 105 patients were included in the study (53 in the CPP group and 52 in the control group). The following were used as the CPP diagnostic criteria; breast development, basal LH measurement higher than 0.3 IU/L, peak LH level ≥ 5 IU/L, peak LH/FSH ratio ≥ 0.66 (after 0.1 mg GnRH stimulation test) and a difference of at least 1 year between bone and chronological age.
A statistically significant difference was detected between the groups in serum Omentin-1 and Chemerin levels, and no significant differences were detected between the groups in Visfatin values. The cut-off values for the diagnosis of CPP were calculated as ≤ 48.9 with 81% sensitivity and 54% specificity for Omentin-1, and as ≥ 417 with 85% sensitivity and 60% specificity for Chemerin.
In our study, we found that Omentin-1 level decreased and Chemerin level increased in lean girls with CPP. More studies are needed to elucidate how adipokines play roles in explaining the onset of CPP, and whether they may be used as a reliable marker for the diagnosis of CPP.
脂肪组织通过分泌多种被称为脂肪因子的激素发挥重要的内分泌功能，如内脂素、网膜素-1和趋化素。另一方面，这些激素也可由女童生殖系统中除脂肪组织外的其他部位分泌。本研究的目的是证实中枢性性早熟（CPP）患者脂肪因子的分泌状态及其在性早熟诊断中的作用。
本研究共纳入105例患者（CPP组53例，对照组52例）。采用以下标准诊断CPP；乳房发育、基础促黄体生成素（LH）测量值高于0.3 IU/L、LH峰值水平≥5 IU/L、LH/FSH峰值比值≥0.66（0.1 mg促性腺激素释放激素（GnRH）刺激试验后）以及骨龄与实际年龄相差至少1岁。
两组血清网膜素-1和趋化素水平存在统计学显著差异，而两组内脂素值无显著差异。诊断CPP时，网膜素-1的截断值计算为≤48.9，敏感性为81%，特异性为54%；趋化素的截断值计算为≥417，敏感性为85%，特异性为60%。
在我们的研究中，我们发现患有CPP的消瘦女童中网膜素-1水平降低，趋化素水平升高。需要更多研究来阐明脂肪因子在解释CPP发病过程中如何发挥作用，以及它们是否可作为CPP诊断的可靠标志物。
