Streinu Diana-Raluca, Neagoe Octavian Constantin, Borlea Andreea, Icma Ion, Derban Mihnea, Stoian Dana
Department of Doctoral Studies, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Front Endocrinol (Lausanne). 2024 Aug 27;15:1438063. doi: 10.3389/fendo.2024.1438063. eCollection 2024.
This study aimed to evaluate the effectiveness of thyroid fine needle aspiration cytology (FNAC) using a novel-cell preserving matrix called Cytomatrix in improving diagnostic accuracy for thyroid nodules.
Fifty patients undergoing thyroidectomy were enrolled and FNAC was performed on the excised thyroid glands, with the collected sample being placed on the Cytomatrix. The results were compared with histopathological analysis, and diagnostic performance was assessed statistically.
Cytomatrix demonstrated an accuracy of 96%, sensitivity of 84.61%, and specificity of 100%. Concordance between cytological and histopathological findings highlighted Cytomatrix's potential to enhance thyroid FNAC accuracy.
FNAC using Cytomatrix shows promise in improving diagnostic accuracy for thyroid nodules. Its application, marked by faster processing and efficient resource utilization, coupled with the preservation of cellular architecture, holds considerable potential in enhancing cytological diagnosis, thus optimizing patient management strategies.
本研究旨在评估使用一种名为细胞基质（Cytomatrix）的新型细胞保存基质进行甲状腺细针穿刺活检（FNAC）对提高甲状腺结节诊断准确性的有效性。
招募50例行甲状腺切除术的患者，对切除的甲状腺进行FNAC，将采集的样本置于细胞基质上。将结果与组织病理学分析进行比较，并对诊断性能进行统计学评估。
细胞基质的准确率为96%，灵敏度为84.61%，特异性为100%。细胞学和组织病理学结果之间的一致性突出了细胞基质提高甲状腺FNAC准确性的潜力。
使用细胞基质的FNAC在提高甲状腺结节诊断准确性方面显示出前景。其应用具有处理速度更快、资源利用高效的特点，再加上细胞结构的保存，在增强细胞学诊断方面具有相当大的潜力，从而优化患者管理策略。
