Hands L J, Royle G T, Kettlewell M G
Br J Surg. 1985 Aug;72(8):665-7. doi: 10.1002/bjs.1800720828.
The vitamin K requirements of 47 adult patients on total parenteral nutrition (TPN) were investigated by randomly allocating them to receive either 0.15 mg vitamin K1 (1 ampoule of 'Vitlipid') per week or 20.15 mg vitamin K1 (1 ampoule of 'Vitlipid' plus 10 mg vitamin K X 2) per week. Vitamin K1 in a dose of 0.15 mg was as effective as a dose of 20.15 mg per week in maintaining a normal BCR (British Corrected Ratio) in most TPN patients. Seven patients in each group developed a BCR greater than 1.3; this was significantly associated with the use of cephalosporin antibiotics and responded to 10 mg vitamin K1 per day. Most patients receiving parenteral feeding require no more vitamin K than that provided by 1 ampoule of 'Vitlipid' per week. Regular monitoring of the BCR, especially in patients on antibiotics, will reveal those who need more. Such patients need 10 mg vitamin K1 per day.
通过随机分配47例接受全胃肠外营养（TPN）的成年患者，使其每周分别接受0.15毫克维生素K1（1支“维他利匹特”）或20.15毫克维生素K1（1支“维他利匹特”加10毫克维生素K×2），对他们的维生素K需求进行了研究。在大多数TPN患者中，0.15毫克剂量的维生素K1在维持正常的英国校正比值（BCR）方面与每周20.15毫克剂量的效果相同。每组有7例患者的BCR大于1.3；这与使用头孢菌素类抗生素显著相关，且每天给予10毫克维生素K1后有反应。大多数接受肠外营养的患者所需的维生素K不比每周1支“维他利匹特”提供的量更多。定期监测BCR，尤其是对抗生素治疗的患者，将发现那些需要更多维生素K的患者。这类患者每天需要10毫克维生素K1。
