Andola Sainath K, Andola Umadevi S, Andola Shruthi S, Antony Anu T, Masgal Meenakshi, Patil Anuradha G, Andola Krutika S
Department of Pathology, Mahadevappa Rampure Medical College, Gulbarga, Karnataka India.
Department of Obstetrics and Gynaecology, Mahadevappa Rampure Medical College, Gulbarga, Karnataka India.
J Obstet Gynaecol India. 2024 Aug;74(4):311-318. doi: 10.1007/s13224-023-01828-x. Epub 2024 Feb 14.
To study the cytomorphological differences of both techniques and to study the relative advantages and limitations of both techniques.
A total of five hundred cases were collected. The conventional Pap smears (CPS) were prepared with cytobrush, and the same brush head was suspended in LBC vial and processed by SurePath.
Of the 500 cases studied, the age ranged from 21 to 80 years with a mean of 40.02. The number of satisfactory smears in CPS and LBC was 490 and 496 cases, respectively. In conventional method, 417 cases (83.4%) and LBC 430 cases (86.0%) were inflammatory smears. The number of LSIL was 18 in conventional method and 15 in LBC. HSIL was 11 in CPS and 10 in LBC, and 8 squamous cell carcinoma cases were seen in LBC. Histopathological correlation was observed in 19 cases of which LBC showed sensitivity and specificity of 100%.
LBC may be considered better than conventional Pap smear due to better adequacy, clarity of background, detection of infections and increased sensitivity and specificity in detecting LSIL and HSIL.
研究两种技术的细胞形态学差异，并探讨两种技术的相对优势和局限性。
共收集500例病例。用细胞刷制备传统巴氏涂片（CPS），将同一刷头悬浮于液基薄层制片（LBC）瓶中，采用SurePath法处理。
在研究的500例病例中，年龄范围为21至80岁，平均年龄为40.02岁。CPS和LBC中满意涂片的病例数分别为490例和496例。传统方法中，417例（83.4%）为炎症涂片，LBC中430例（86.0%）为炎症涂片。传统方法中低级别鳞状上皮内病变（LSIL）有18例，LBC中有15例。高级别鳞状上皮内病变（HSIL）在CPS中有11例，LBC中有10例，LBC中发现8例鳞状细胞癌病例。观察到19例有组织病理学相关性，其中LBC的敏感性和特异性均为100%。
由于LBC涂片的取材充足、背景清晰、能检测感染，以及在检测LSIL和HSIL方面具有更高的敏感性和特异性，因此可认为LBC优于传统巴氏涂片。
