Khakwani Mehnaz, Parveen Rashida, Azhar Maryam
Mehnaz Khakwani, FCPS. Department of Obstetrics and Gyne, Unit-1, Nishtar Medical University, Multan, Pakistan.
Rashida Parveen, FCPS. Department of Obstetrics and Gyne, Unit-1, Nishtar Medical University, Multan, Pakistan.
Pak J Med Sci. 2022 Sep-Oct;38(7):1827-1831. doi: 10.12669/pjms.38.7.5742.
To compare conventional PAP smear (CPS) and liquid-based cytology (LBC) for cervical carcinoma screening at a tertiary care hospital of South Punjab, Pakistan.
This cross-sectional study was conducted at the Department of Obstetrics and Gynecology, Nishtar Hospital, Multan, Pakistan from January 2021 to June 2021. We included a total of 265 women aged between 20 to 65 years who, presented with complaints related to cervical lesion and unhealthy cervix. The CPS and LBC methods were applied for screening of cervical carcinoma. Findings of both CPS and LBC were compared with histopathological findings to find out sensitivity, specificity, positive predictive value and negative predictive value for both techniques.
In a total of 265 women, mean age was noted to be 45.4±6.8 years. White discharge per vagina was the commonest presenting complaint noted in 12 (46.8%) patients. Satisfactory smears were found in significantly more cases with LBC in comparison to CPS (p<0.001). Sensitivity CPS and LBC for the detection of low-grade squamous intraepithelial lesion (LSIL) were found to be 71.8% and 87.2% while for high-grade squamous intraepithelial lesion (HSIL), sensitivity of CPS and LBC were 61.9% and 76.2% respectively. Specificity of CPS and LBC for the detection of LSIL was found to be 97.9% and 98.7% while for HSIL, specificity of CPS and LBC was 98.7% and 99.2% respectively.
In comparison to conventional CPS, LBC was found to be better in terms of adequacy of smear and identification of LSIL and HSIL.
在巴基斯坦旁遮普省南部的一家三级护理医院比较传统巴氏涂片检查（CPS）和液基细胞学检查（LBC）用于宫颈癌筛查的效果。
这项横断面研究于2021年1月至2021年6月在巴基斯坦木尔坦尼什塔尔医院妇产科进行。我们纳入了总共265名年龄在20至65岁之间、有宫颈病变和宫颈不健康相关主诉的女性。采用CPS和LBC方法进行宫颈癌筛查。将CPS和LBC的结果与组织病理学结果进行比较，以确定两种技术的敏感性、特异性、阳性预测值和阴性预测值。
在总共265名女性中，平均年龄为45.4±6.8岁。12名（46.8%）患者中最常见的主诉是阴道白带增多。与CPS相比，LBC检查发现满意涂片的病例明显更多（p<0.001）。CPS和LBC检测低级别鳞状上皮内病变（LSIL）的敏感性分别为71.8%和87.2%，而检测高级别鳞状上皮内病变（HSIL）时，CPS和LBC的敏感性分别为61.9%和76.2%。CPS和LBC检测LSIL的特异性分别为97.9%和98.7%，而检测HSIL时，CPS和LBC的特异性分别为98.7%和99.2%。
与传统CPS相比，LBC在涂片充分性以及LSIL和HSIL的识别方面表现更好。
