Elamurugan Arun, Nirenjen Shanmugasundaram, Manivannan Arjun Gokulan, Jaishankar Narayanan, Vellapandian Chitra
Pharmacy/Pharmacology, Sri Ramaswamy Memorial College of Pharmacy, Sri Ramaswamy Memorial Institute of Science and Technology, Chennai, IND.
Cureus. 2024 Aug 14;16(8):e66829. doi: 10.7759/cureus.66829. eCollection 2024 Aug.
Kienbock's disease is a rare form of avascular necrosis affecting the lunate bone in the wrist, leading to progressive bone necrosis and functional impairment. The disease's rarity and nonspecific early symptoms present significant diagnostic and treatment challenges. We report the case of a 41-year-old female presenting with chronic left wrist pain and restricted movement without a history of trauma. Her symptoms had progressively worsened over 20 days. Laboratory findings showed an elevated erythrocyte sedimentation rate (ESR) of 14 mm/hour and a slightly prolonged clotting time of 3'30'', while other parameters, including C-reactive protein (CRP), electrolytes, renal function, and blood sugar levels, were within normal ranges. Radiographic imaging indicated lunate collapse, joint space narrowing, subchondral cysts, and secondary osteoarthritis, confirming the diagnosis of Kienbock's disease. Given the severity of her condition, a proximal row carpectomy (PRC) was performed, resulting in significant pain relief and improved wrist function. This case underscores the complexities in diagnosing Kienbock's disease, particularly in regions where it is rare, such as India. The Lichtman classification system was essential in guiding treatment decisions, ranging from conservative measures to surgical interventions. This report highlights the importance of accurate diagnosis and individualized treatment plans in managing Kienbock's disease, demonstrating the efficacy of PRC in advanced stages. It contributes valuable insights into the diagnostic and therapeutic strategies for this rare but impactful condition, emphasizing the need for further research into innovative therapies and preventive measures.
肯博克氏病是一种罕见的缺血性坏死,影响腕部月骨,导致进行性骨坏死和功能障碍。该病的罕见性和非特异性早期症状带来了重大的诊断和治疗挑战。我们报告一例41岁女性病例,该患者无外伤史,出现慢性左腕疼痛和活动受限。其症状在20天内逐渐加重。实验室检查结果显示红细胞沉降率(ESR)升高至14毫米/小时,凝血时间略延长至3分30秒,而其他参数,包括C反应蛋白(CRP)、电解质、肾功能和血糖水平均在正常范围内。影像学检查显示月骨塌陷、关节间隙变窄、软骨下囊肿和继发性骨关节炎,确诊为肯博克氏病。鉴于其病情严重程度,进行了近排腕骨切除术(PRC),术后疼痛明显缓解,腕部功能改善。该病例强调了诊断肯博克氏病的复杂性,尤其是在印度等该病罕见的地区。利希特曼分类系统对于指导治疗决策至关重要,治疗决策范围从保守措施到手术干预。本报告强调了准确诊断和个体化治疗方案在管理肯博克氏病中的重要性,证明了PRC在晚期的疗效。它为这种罕见但有影响的疾病的诊断和治疗策略提供了有价值的见解,强调了对创新疗法和预防措施进行进一步研究的必要性。