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解开谜团:耐甲氧西林金黄色葡萄球菌的隐秘藏身之处

Unraveling the Puzzle: The Secret Hideout of Methicillin-Resistant Staphylococcus aureus.

作者信息

Ansari Fawwad A, Walls Sheri P, Hewlett Dylan, Biney Priscilla E

机构信息

Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.

出版信息

Cureus. 2024 Aug 14;16(8):e66889. doi: 10.7759/cureus.66889. eCollection 2024 Aug.

DOI:10.7759/cureus.66889
PMID:39280462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11398849/
Abstract

Methicillin-resistant (MRSA) is a prevalent nosocomial pathogen known for causing severe disseminated infections. Recently, there has been an increase in community-acquired MRSA infections. We present a case of MRSA bacteremia complicated by a cervical epidural abscess. A 63-year-old female with no significant past medical history presented with altered mental status lasting two days. She had recently experienced neck stiffness after lifting a heavy object, initially diagnosed as torticollis, at an outside facility. On examination, she appeared ill and met the criteria for sepsis. Blood cultures confirmed MRSA. She developed hypotension, and an MRI of the brain and cervical spine revealed leptomeningeal enhancement and an epidural abscess. MRSA bacteremia, although common, can manifest in various forms. While it typically occurs in patients with identifiable risk factors, our patient had none. Identifying the source of bacteremia is crucial, as effective treatment requires both source control and antibiotic therapy. Given MRSA's high morbidity and mortality, a thorough and rigorous approach to assessment and management is essential.

摘要

耐甲氧西林金黄色葡萄球菌(MRSA)是一种常见的医院病原体,以引起严重的播散性感染而闻名。最近,社区获得性MRSA感染有所增加。我们报告一例并发颈椎硬膜外脓肿的MRSA菌血症病例。一名63岁女性,既往无重大病史,出现精神状态改变持续两天。她最近在搬重物后出现颈部僵硬,最初在外院被诊断为斜颈。检查时,她看起来病情严重,符合脓毒症标准。血培养确诊为MRSA。她出现低血压,脑部和颈椎的MRI显示软脑膜强化和硬膜外脓肿。MRSA菌血症虽然常见,但可表现为多种形式。虽然它通常发生在有明确危险因素的患者中,但我们的患者没有这些危险因素。确定菌血症的来源至关重要,因为有效的治疗需要源头控制和抗生素治疗。鉴于MRSA的高发病率和死亡率,采用全面而严谨的评估和管理方法至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11398849/0371a920c3ca/cureus-0016-00000066889-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11398849/0371a920c3ca/cureus-0016-00000066889-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11398849/0371a920c3ca/cureus-0016-00000066889-i01.jpg

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本文引用的文献

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Current Paradigms of Combination Therapy in Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: Does it Work, Which Combination, and For Which Patients?耐甲氧西林金黄色葡萄球菌(MRSA)菌血症的联合治疗现状:是否有效、哪种联合治疗、针对哪些患者?
Clin Infect Dis. 2021 Dec 16;73(12):2353-2360. doi: 10.1093/cid/ciab452.
2
MRSA Spinal Epidural Abscess as a Neurosurgical and Infectious Disease Emergency with Unresolved Antimicrobial Solution.耐甲氧西林金黄色葡萄球菌脊柱硬膜外脓肿作为一种神经外科和传染病急症,抗菌治疗方案尚未解决。
Case Rep Infect Dis. 2019 Jan 30;2019:7413089. doi: 10.1155/2019/7413089. eCollection 2019.
3
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.
耐甲氧西林金黄色葡萄球菌:分子特征、进化与流行病学。
Clin Microbiol Rev. 2018 Sep 12;31(4). doi: 10.1128/CMR.00020-18. Print 2018 Oct.
4
Disseminated MRSA infection with purulent pericarditis.播散性耐甲氧西林金黄色葡萄球菌感染伴脓性心包炎。
BMJ Case Rep. 2017 Mar 30;2017:bcr-2016-218463. doi: 10.1136/bcr-2016-218463.
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Methicillin-resistant Staphylococcus aureus meningitis in adults: a multicenter study of 86 cases.成人耐甲氧西林金黄色葡萄球菌脑膜炎:86例多中心研究
Medicine (Baltimore). 2012 Jan;91(1):10-17. doi: 10.1097/MD.0b013e318243442b.
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The changing epidemiology of Staphylococcus aureus?金黄色葡萄球菌流行病学的变化?
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